FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907046134> ?p ?o ?g. }

• W2907046134 endingPage "522" @default.
• W2907046134 startingPage "513" @default.
• W2907046134 abstract "This chapter focuses on research aimed at understanding the mechanism by which PtdIns(3,4,5)P 3 regulates one branch of its downstream signaling pathways, namely enabling PDK1 to phosphorylate and activate a group of serine/threonine protein kinases that belong to the AGC subfamily of protein kinases. These include isoforms of PKB, p70 ribosomal S6 kinase (S6K), serum- and glucocorticoid-induced protein kinase (SGK), p90 ribosomal S6 kinase (RSK), and protein kinase C (PKC) isoforms. Once these diverse AGC kinase members are activated, they phosphorylate and change the activity and function of key regulatory proteins that control processes such as cell proliferation and survival as well as cellular responses to insulin. The results discussed in this chapter also provide a framework within which drugs could be developed to inhibit the PDK1/AGC kinase pathway to treat forms of cancers in which this pathway may be constitutively activated. Indeed, it is now estimated that PTEN is mutated in up to 30% of all human tumors, resulting in elevated PtdIns(3,4,5)P 3 levels and hence PKB and S6K activity which are likely to contribute to the proliferation and survival of these tumors. It could be envisaged that a PDK1 inhibitor would be effective at reducing the PKB and S6K activities that contribute to growth and survival of these tumors." @default.
• W2907046134 created "2019-01-11" @default.
• W2907046134 creator A5054181982 @default.
• W2907046134 date "2003-01-01" @default.
• W2907046134 modified "2023-09-24" @default.
• W2907046134 title "Role of PDK1 in Activating AGC Protein Kinase" @default.
• W2907046134 cites W1493922188 @default.
• W2907046134 cites W1495179683 @default.
• W2907046134 cites W1534104940 @default.
• W2907046134 cites W1573413160 @default.
• W2907046134 cites W1591640849 @default.
• W2907046134 cites W1876033686 @default.
• W2907046134 cites W1908445283 @default.
• W2907046134 cites W1909702956 @default.
• W2907046134 cites W1921832013 @default.
• W2907046134 cites W1963825704 @default.
• W2907046134 cites W1966533220 @default.
• W2907046134 cites W1973837499 @default.
• W2907046134 cites W1974241409 @default.
• W2907046134 cites W1974530349 @default.
• W2907046134 cites W1979612739 @default.
• W2907046134 cites W1986873843 @default.
• W2907046134 cites W1991468122 @default.
• W2907046134 cites W1993835711 @default.
• W2907046134 cites W1999163644 @default.
• W2907046134 cites W2001121496 @default.
• W2907046134 cites W2004078164 @default.
• W2907046134 cites W2004922458 @default.
• W2907046134 cites W2004926623 @default.
• W2907046134 cites W2004934164 @default.
• W2907046134 cites W2005691833 @default.
• W2907046134 cites W2010422684 @default.
• W2907046134 cites W2012594643 @default.
• W2907046134 cites W2015239877 @default.
• W2907046134 cites W2015674575 @default.
• W2907046134 cites W2017191360 @default.
• W2907046134 cites W2017370430 @default.
• W2907046134 cites W2017394099 @default.
• W2907046134 cites W2020329164 @default.
• W2907046134 cites W2020931266 @default.
• W2907046134 cites W2022090845 @default.
• W2907046134 cites W2023934239 @default.
• W2907046134 cites W2024220711 @default.
• W2907046134 cites W2025851393 @default.
• W2907046134 cites W2026987638 @default.
• W2907046134 cites W2028970288 @default.
• W2907046134 cites W2029219396 @default.
• W2907046134 cites W2032318138 @default.
• W2907046134 cites W2035648799 @default.
• W2907046134 cites W2039185825 @default.
• W2907046134 cites W2039193709 @default.
• W2907046134 cites W2040143421 @default.
• W2907046134 cites W2041926656 @default.
• W2907046134 cites W2042746242 @default.
• W2907046134 cites W2044005459 @default.
• W2907046134 cites W2044868069 @default.
• W2907046134 cites W2046525768 @default.
• W2907046134 cites W2052550515 @default.
• W2907046134 cites W2053073281 @default.
• W2907046134 cites W2056158543 @default.
• W2907046134 cites W2057688589 @default.
• W2907046134 cites W2059034341 @default.
• W2907046134 cites W2059692699 @default.
• W2907046134 cites W2064242629 @default.
• W2907046134 cites W2065547075 @default.
• W2907046134 cites W2065652048 @default.
• W2907046134 cites W2065978566 @default.
• W2907046134 cites W2066469176 @default.
• W2907046134 cites W2069720095 @default.
• W2907046134 cites W2070732456 @default.
• W2907046134 cites W2075725057 @default.
• W2907046134 cites W2075767774 @default.
• W2907046134 cites W2075776349 @default.
• W2907046134 cites W2076684078 @default.
• W2907046134 cites W2079123009 @default.
• W2907046134 cites W2081598827 @default.
• W2907046134 cites W2091275711 @default.
• W2907046134 cites W2099389441 @default.
• W2907046134 cites W2099767283 @default.
• W2907046134 cites W2103941658 @default.
• W2907046134 cites W2105347265 @default.
• W2907046134 cites W2107813980 @default.
• W2907046134 cites W2111752734 @default.
• W2907046134 cites W2114990983 @default.
• W2907046134 cites W2117029515 @default.
• W2907046134 cites W2120138780 @default.
• W2907046134 cites W2121810961 @default.
• W2907046134 cites W2122005428 @default.
• W2907046134 cites W2126404692 @default.
• W2907046134 cites W2129742695 @default.
• W2907046134 cites W2135458863 @default.
• W2907046134 cites W2135596918 @default.
• W2907046134 cites W2140439371 @default.
• W2907046134 cites W2141600950 @default.
• W2907046134 cites W2142060283 @default.
• W2907046134 cites W2144005841 @default.
• W2907046134 cites W2146157811 @default.
• W2907046134 cites W2146989813 @default.

• next