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- W2907055115 abstract "Introduction: Arteriovenous access dysfunction is still the Achilles’ heel of hemodialysis in patients with end-stage renal disease (ESRD) with a 1-year primary patency of only 60%.The pathophysiology of arteriovenous fistula (AVF) maturation failure is unknown but impaired outward remodeling and intimal hyperplasia are both considered to contribute. Radio protective (RP)105 is an important regulator of inflammatory TLR4 signalling, expressed on numerous cell types. In the present study, we defined cell specific effects of RP105-/- on vascular smooth muscle cells (VSMCs) and macrophages (mφ) in vitro and in vivo effects of RP105-/- on AVF maturation in a murine model of AVF failure. Methods: All in vitro experiments were performed on primary cells isolated from RP105-/- and wild type (WT) mice. AVFs were created in an end-to-side manner between v.jugularis and carotid a. in RP105-/- (n=13) and WT (n=11) mice. AVFs were harvested at day 14 and processed for morphometric analysis and immunohistochemistry. M..." @default.
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- W2907055115 date "2016-11-11" @default.
- W2907055115 modified "2023-09-28" @default.
- W2907055115 title "Abstract 15608: Deficiency of Tlr4 Homologue Rp105 Aggravates Outward Remodelling in a Murine Model of Arteriovenous Fistula Failure" @default.
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