FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907063312> ?p ?o ?g. }

• W2907063312 abstract "The inner membrane complex (IMC) is a defining feature of apicomplexans comprising of lipid and protein components involved in gliding motility and host cell invasion. Motility of Plasmodium parasites is accomplished by an actin and myosin based glideosome machinery situated between the parasite plasma membrane (PPM) and IMC. Here, we have studied in vivo expression and localization of a Plasmodium falciparum (Pf) IMC protein 'PfIMC1l' and characterized it functionally by using biochemical assays. We have identified cytoskeletal protein 'actin' and motor protein 'myosin' as novel binding partners of PfIMC1l, alongside its interaction with the lipids 'cholesterol' and 'phosphatidyl-inositol 4, 5 bisphosphate' (PIP2). While actin and myosin compete for interaction with PfIMC1l, actin and either of the lipids (cholesterol or PIP2) simultaneously bind PfIMC1l. Interestingly, PfIMC1l showed enhanced binding with actin in the presence of calcium ions, and displayed direct binding with calcium. Based on our in silico analysis and experimental data showing PfIMC1l-actin/myosin and PfIMC1l-lipid interactions, we propose that this protein may anchor the IMC membrane with the parasite gliding apparatus. Considering its binding with key proteins involved in motility viz. myosin and actin (with calcium dependence), we suggest that PfIMC1l may have a role in the locomotion of Plasmodium." @default.
• W2907063312 created "2019-01-11" @default.
• W2907063312 creator A5001968958 @default.
• W2907063312 creator A5005448992 @default.
• W2907063312 creator A5012744982 @default.
• W2907063312 creator A5019863978 @default.
• W2907063312 creator A5035336391 @default.
• W2907063312 creator A5037388145 @default.
• W2907063312 creator A5039613174 @default.
• W2907063312 creator A5053537530 @default.
• W2907063312 creator A5084550328 @default.
• W2907063312 creator A5090369986 @default.
• W2907063312 date "2019-04-01" @default.
• W2907063312 modified "2023-09-25" @default.
• W2907063312 title "Inner membrane complex 1l protein of Plasmodium falciparum links membrane lipids with cytoskeletal element ‘actin’ and its associated motor ‘myosin’" @default.
• W2907063312 cites W1524992328 @default.
• W2907063312 cites W1596599463 @default.
• W2907063312 cites W1798402781 @default.
• W2907063312 cites W1923119978 @default.
• W2907063312 cites W1963097328 @default.
• W2907063312 cites W1973589145 @default.
• W2907063312 cites W1974978555 @default.
• W2907063312 cites W1978029175 @default.
• W2907063312 cites W1981494071 @default.
• W2907063312 cites W1984322384 @default.
• W2907063312 cites W1996338896 @default.
• W2907063312 cites W1999943991 @default.
• W2907063312 cites W2004736974 @default.
• W2907063312 cites W2014645398 @default.
• W2907063312 cites W2020819397 @default.
• W2907063312 cites W2025636478 @default.
• W2907063312 cites W2026422868 @default.
• W2907063312 cites W2026757666 @default.
• W2907063312 cites W2027860190 @default.
• W2907063312 cites W2029793345 @default.
• W2907063312 cites W2046945218 @default.
• W2907063312 cites W2050163332 @default.
• W2907063312 cites W2056325046 @default.
• W2907063312 cites W2057308243 @default.
• W2907063312 cites W2071979597 @default.
• W2907063312 cites W2077240061 @default.
• W2907063312 cites W2080673392 @default.
• W2907063312 cites W2091936869 @default.
• W2907063312 cites W2095738140 @default.
• W2907063312 cites W2096232409 @default.
• W2907063312 cites W2101144468 @default.
• W2907063312 cites W2104057588 @default.
• W2907063312 cites W2126401103 @default.
• W2907063312 cites W2129628333 @default.
• W2907063312 cites W2138305150 @default.
• W2907063312 cites W2140952049 @default.
• W2907063312 cites W2142044718 @default.
• W2907063312 cites W2153882454 @default.
• W2907063312 cites W2154031783 @default.
• W2907063312 cites W2157331313 @default.
• W2907063312 cites W2163672006 @default.
• W2907063312 cites W2171122741 @default.
• W2907063312 cites W2570769655 @default.
• W2907063312 cites W2761601692 @default.
• W2907063312 cites W2769931941 @default.
• W2907063312 cites W2953300746 @default.
• W2907063312 cites W4249424055 @default.
• W2907063312 doi "https://doi.org/10.1016/j.ijbiomac.2018.12.239" @default.
• W2907063312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30599160" @default.
• W2907063312 hasPublicationYear "2019" @default.
• W2907063312 type Work @default.
• W2907063312 sameAs 2907063312 @default.
• W2907063312 citedByCount "5" @default.
• W2907063312 countsByYear W29070633122020 @default.
• W2907063312 countsByYear W29070633122021 @default.
• W2907063312 countsByYear W29070633122023 @default.
• W2907063312 crossrefType "journal-article" @default.
• W2907063312 hasAuthorship W2907063312A5001968958 @default.
• W2907063312 hasAuthorship W2907063312A5005448992 @default.
• W2907063312 hasAuthorship W2907063312A5012744982 @default.
• W2907063312 hasAuthorship W2907063312A5019863978 @default.
• W2907063312 hasAuthorship W2907063312A5035336391 @default.
• W2907063312 hasAuthorship W2907063312A5037388145 @default.
• W2907063312 hasAuthorship W2907063312A5039613174 @default.
• W2907063312 hasAuthorship W2907063312A5053537530 @default.
• W2907063312 hasAuthorship W2907063312A5084550328 @default.
• W2907063312 hasAuthorship W2907063312A5090369986 @default.
• W2907063312 hasConcept C125705527 @default.
• W2907063312 hasConcept C130861313 @default.
• W2907063312 hasConcept C142669718 @default.
• W2907063312 hasConcept C1491633281 @default.
• W2907063312 hasConcept C2993400109 @default.
• W2907063312 hasConcept C3620293 @default.
• W2907063312 hasConcept C55493867 @default.
• W2907063312 hasConcept C58207958 @default.
• W2907063312 hasConcept C64745115 @default.
• W2907063312 hasConcept C6997183 @default.
• W2907063312 hasConcept C86803240 @default.
• W2907063312 hasConcept C95444343 @default.
• W2907063312 hasConceptScore W2907063312C125705527 @default.
• W2907063312 hasConceptScore W2907063312C130861313 @default.
• W2907063312 hasConceptScore W2907063312C142669718 @default.
• W2907063312 hasConceptScore W2907063312C1491633281 @default.
• W2907063312 hasConceptScore W2907063312C2993400109 @default.
• W2907063312 hasConceptScore W2907063312C3620293 @default.

• next