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- W2907117150 abstract "e13546 Background: DPD deficiency is associated with severe toxicity after 5-FU treatment. There are regional differences in tolerance to 5-FU. No data about toxicity to 5-FU in cancer patients in northern Brazil. No data evaluating polymorphisms in DPYD and toxicity to 5-FU in admixed populations. The aim was to evaluate the relation of two DPYD polymorphisms (*2 and *5) with toxicity in cancer patients treated with fluoropyrimidines in admixture population. Methods: A cross-sectional study was done, including cancer patients treated with fluoropyrimidines in 3 oncology center in Belem, northern Brazil. Clinical data were recovered from medical records. Analysis of polymorphisms has used TaqMan® system. 48 markers ancestry informative have been used as genomic control method. The Structure v.22 software was used to estimate the individual and overall proportion of ancestry. Results: 151 patients treated with fluoropyrimidines were included. The mean age was 55.3 years (range 18-86) and 52.7% of the sample were men. Colorectal cancer (44,7%) and gastric câncer (39,9%) were more common primary site. 5-FU alone was used in 45% of cases and the average number of cycles was 5.98 (range 1-24). The averages ancestries were 62.4% European, 25.2% Native American and 12.4% African. Among patients with available information, 80 (70.8 %) had some degree of toxicity (grade 1-4), while only 18 (15.9 %) had severe toxicity (grade 3 and 4). There was one death related to 5-FU toxicity. The homozygous for the polymorphism DPYD*5 was related to the 8-fold increase in the occurrence of severe toxicity (p=0.037). No DPYD*2 polymorphism was found. There was a significant correlation between the occurrence of any toxicity and African ancestry (p = 0.035). Although not statistically significant, the average African ancestry was higher in patients with severe toxicity (p = 0.185). The Native American ancestry showed a trend of protection against severe toxicity (p = 0.059). Conclusions: The data reinforce the importance of variations in the DPYD in fluoropyrimidines tolerance and suggest the control of ancestry as importante factor to personalize chemotherapy in admixed populations." @default.
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- W2907117150 date "2014-05-20" @default.
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- W2907117150 title "Dihydropyrimidine dehydrogenase gene (DPYD) polymorphisms associated with toxicity in patients treated with flourpyrimidines in northern Brazil." @default.
- W2907117150 doi "https://doi.org/10.1200/jco.2014.32.15_suppl.e13546" @default.
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