Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907117515> ?p ?o ?g. }
- W2907117515 abstract "ABSTRACT Cellular ability to maintain proper protein homeostasis (proteostasis) is essential for survival upon protein-damaging conditions. Heat shock transcription factor 2 (HSF2) is one of the human HSFs activated in response to proteotoxic stress. HSF2 is dispensable for cell survival during acute heat stress, but its amount and DNA-binding activity increase under prolonged proteotoxic stress conditions, such as proteasome inhibition. Nevertheless, the specific role(s) of HSF2 and the global HSF2-dependent gene expression profile during sustained stress have remained elusive. We found that HSF2 is required for cell survival during prolonged proteotoxicity, as shown by treating wild-type and HSF2-deficient human osteosarcoma U2OS cells with the proteasome inhibitor Bortezomib. Strikingly, our RNA-seq analyses revealed that HSF2 disruption leads to marked downregulation of cadherin superfamily genes and subsequent functional impairment of cadherin-mediated cell-cell adhesion. We propose HSF2 as a key regulator of genes belonging to the cadherin superfamily. We also demonstrate that HSF2-dependent downregulation of cadherin-mediated cell-cell adhesion predisposes U2OS cells to Bortezomib-induced proteotoxic stress. In conclusion, we show that by maintaining cell-cell adhesion HSF2 is essential for cell survival and thereby we describe a novel regime in the HSF-mediated protection against stress-induced protein damage." @default.
- W2907117515 created "2019-01-11" @default.
- W2907117515 creator A5002704963 @default.
- W2907117515 creator A5007027974 @default.
- W2907117515 creator A5010412693 @default.
- W2907117515 creator A5013700617 @default.
- W2907117515 creator A5024658242 @default.
- W2907117515 creator A5038962674 @default.
- W2907117515 creator A5046598461 @default.
- W2907117515 creator A5072187977 @default.
- W2907117515 creator A5077805337 @default.
- W2907117515 creator A5083394465 @default.
- W2907117515 date "2018-12-27" @default.
- W2907117515 modified "2023-10-01" @default.
- W2907117515 title "HSF2 protects against proteotoxicity by maintaining cell-cell adhesion" @default.
- W2907117515 cites W1598718570 @default.
- W2907117515 cites W1881688083 @default.
- W2907117515 cites W1904178031 @default.
- W2907117515 cites W1971108880 @default.
- W2907117515 cites W1971317316 @default.
- W2907117515 cites W1974500967 @default.
- W2907117515 cites W1975663753 @default.
- W2907117515 cites W1977502249 @default.
- W2907117515 cites W1977603207 @default.
- W2907117515 cites W1980291812 @default.
- W2907117515 cites W1992624136 @default.
- W2907117515 cites W1995752576 @default.
- W2907117515 cites W2013683245 @default.
- W2907117515 cites W2025974453 @default.
- W2907117515 cites W2032840272 @default.
- W2907117515 cites W2036053197 @default.
- W2907117515 cites W2040359453 @default.
- W2907117515 cites W2046314862 @default.
- W2907117515 cites W2047333140 @default.
- W2907117515 cites W2049743082 @default.
- W2907117515 cites W2056530510 @default.
- W2907117515 cites W2069183779 @default.
- W2907117515 cites W2079768191 @default.
- W2907117515 cites W2080050467 @default.
- W2907117515 cites W2080834659 @default.
- W2907117515 cites W2089400513 @default.
- W2907117515 cites W2089742961 @default.
- W2907117515 cites W2093304538 @default.
- W2907117515 cites W2094730469 @default.
- W2907117515 cites W2099395323 @default.
- W2907117515 cites W2104693303 @default.
- W2907117515 cites W2108808474 @default.
- W2907117515 cites W2112064435 @default.
- W2907117515 cites W2119624960 @default.
- W2907117515 cites W2119975980 @default.
- W2907117515 cites W2121377075 @default.
- W2907117515 cites W2122683221 @default.
- W2907117515 cites W2124733101 @default.
- W2907117515 cites W2135405389 @default.
- W2907117515 cites W2141693487 @default.
- W2907117515 cites W2146512944 @default.
- W2907117515 cites W2150510467 @default.
- W2907117515 cites W2150990088 @default.
- W2907117515 cites W2153475997 @default.
- W2907117515 cites W2155324869 @default.
- W2907117515 cites W2156225959 @default.
- W2907117515 cites W2159914115 @default.
- W2907117515 cites W2160167196 @default.
- W2907117515 cites W2166987747 @default.
- W2907117515 cites W2229818272 @default.
- W2907117515 cites W2306540679 @default.
- W2907117515 cites W2329900712 @default.
- W2907117515 cites W2341194710 @default.
- W2907117515 cites W2499150495 @default.
- W2907117515 cites W2526226642 @default.
- W2907117515 cites W2580035316 @default.
- W2907117515 cites W2595269718 @default.
- W2907117515 cites W2652717092 @default.
- W2907117515 cites W2743018412 @default.
- W2907117515 cites W2750745925 @default.
- W2907117515 cites W2782732374 @default.
- W2907117515 cites W2792730597 @default.
- W2907117515 cites W2901163212 @default.
- W2907117515 cites W4230741679 @default.
- W2907117515 doi "https://doi.org/10.1101/506881" @default.
- W2907117515 hasPublicationYear "2018" @default.
- W2907117515 type Work @default.
- W2907117515 sameAs 2907117515 @default.
- W2907117515 citedByCount "0" @default.
- W2907117515 crossrefType "posted-content" @default.
- W2907117515 hasAuthorship W2907117515A5002704963 @default.
- W2907117515 hasAuthorship W2907117515A5007027974 @default.
- W2907117515 hasAuthorship W2907117515A5010412693 @default.
- W2907117515 hasAuthorship W2907117515A5013700617 @default.
- W2907117515 hasAuthorship W2907117515A5024658242 @default.
- W2907117515 hasAuthorship W2907117515A5038962674 @default.
- W2907117515 hasAuthorship W2907117515A5046598461 @default.
- W2907117515 hasAuthorship W2907117515A5072187977 @default.
- W2907117515 hasAuthorship W2907117515A5077805337 @default.
- W2907117515 hasAuthorship W2907117515A5083394465 @default.
- W2907117515 hasBestOaLocation W29071175151 @default.
- W2907117515 hasConcept C104317684 @default.
- W2907117515 hasConcept C136238340 @default.
- W2907117515 hasConcept C139447449 @default.
- W2907117515 hasConcept C1491633281 @default.