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- W2907150880 abstract "Luteinizing hormone (Lh) and follicle-stimulating hormone (Fsh) control reproduction in vertebrates. Using a transgenic line of medaka, in which green fluorescent protein expression is controlled by the endogenous lhb promotor, we studied development and plasticity of Lh cells, comparing juveniles and adults of both genders. Confocal imaging and 3D reconstruction revealed hypertrophy and hyperplasia of Lh cells in both genders from juvenile to adult stages. We show that Lh cell hyperplasia may be caused by recruitment of existing pituitary cells that start to produce lhb , as evidenced by time lapse recordings of primary pituitary cell cultures, and/or through Lh cell proliferation, demonstrated through a combination of 5-bromo-2′-deoxyuridine incubation experiments and proliferating cell nuclear antigen staining. Proliferating Lh cells do not belong to the classical type of multipotent stem cells, as they do not stain with anti- sox2 . Estradiol exposure in vivo increased pituitary cell proliferation, particularly Lh cells, whereas pituitary lhb and gpa expression levels decreased. RNA-seq and in situ hybridization showed that Lh cells express two estrogen receptors, esr1 and esr2b , and the aromatase gene cyp19a1b , suggesting a direct effect of estradiol, and possibly androgens, on Lh cell proliferation. In conclusion, our study reveals a high degree of plasticity in the medaka Lh cell population, resulting from a combination of recruitment and cell proliferation." @default.
- W2907150880 created "2019-01-11" @default.
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- W2907150880 creator A5065259494 @default.
- W2907150880 creator A5076583909 @default.
- W2907150880 creator A5078815544 @default.
- W2907150880 date "2019-02-01" @default.
- W2907150880 modified "2023-10-17" @default.
- W2907150880 title "Plasticity of Lh cells caused by cell proliferation and recruitment of existing cells" @default.
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- W2907150880 cites W1964891995 @default.
- W2907150880 cites W1967712174 @default.
- W2907150880 cites W1967768414 @default.
- W2907150880 cites W1970164206 @default.
- W2907150880 cites W1970186168 @default.
- W2907150880 cites W1983265095 @default.
- W2907150880 cites W1983461332 @default.
- W2907150880 cites W1983871586 @default.
- W2907150880 cites W1984858425 @default.
- W2907150880 cites W1988111450 @default.
- W2907150880 cites W1992091822 @default.
- W2907150880 cites W1993786821 @default.
- W2907150880 cites W2001099074 @default.
- W2907150880 cites W2003060172 @default.
- W2907150880 cites W2006048200 @default.
- W2907150880 cites W2011354316 @default.
- W2907150880 cites W2020946349 @default.
- W2907150880 cites W2029176835 @default.
- W2907150880 cites W2030311046 @default.
- W2907150880 cites W2032855950 @default.
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- W2907150880 cites W2136283301 @default.
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- W2907150880 cites W2143246176 @default.
- W2907150880 cites W2153141791 @default.
- W2907150880 cites W2156018218 @default.
- W2907150880 cites W2156755609 @default.
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- W2907150880 cites W2167279371 @default.
- W2907150880 cites W2170219300 @default.
- W2907150880 cites W2546972230 @default.
- W2907150880 cites W2576281370 @default.
- W2907150880 cites W2742414806 @default.
- W2907150880 cites W2742546880 @default.
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- W2907150880 doi "https://doi.org/10.1530/joe-18-0412" @default.
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- W2907150880 hasPublicationYear "2019" @default.
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