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- W2907172076 abstract "Desmosdumotin C (Des C), a natural product isolated from the roots of Desmos dumosus, has shown good antitumor activity. A three dimensional quantitative structure-activity relationship (QSAR) study using the comparative molecular field analysis (CoMFA) method was performed on 32 Des C analogues. Based on the QSAR, 18 new Des C analogues were designed and synthesized. An efficient three-step synthetic strategy toward Des C and its analogues was developed from commercial available 2, 4, 6-trihydroxyacetophenone. All synthesized compounds were evaluated against a panel of human cancer cell lines and showed ED50 values ranging from 1.1 to 25.1 µΜ." @default.
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- W2907172076 date "2018-12-30" @default.
- W2907172076 modified "2023-09-26" @default.
- W2907172076 title "Design, synthesis, and antitumor activity of desmosdumotin C analogues" @default.
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- W2907172076 doi "https://doi.org/10.1080/10286020.2018.1473383" @default.
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