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- W2907174775 abstract "The effect of ionizing radiation in loss of the ability of an otherwise actively dividing somatic cell to continue its division and production of progeny is almost certainly due to defects in the DNA that interfere with the replicative and mitotic process. Since all the genetic information carried by the cell is in the same DNA molecules in which this damage is declared to exist, it is only reasonable to suggest that the same mechanisms that lead to loss of clonogenic potential in somatic cells will also lead to possible loss of, or alterations in, the genomic information carried in the cell. This loss of genomic information is expressed as a change in the gene complement of the cell, and if the genomic change exists in the gametes of the radiated subject, these changes may be passed on to future generations at the time of reproductive activity. There are two classes of damage that have been shown to result from ionizing radiation exposure: stochastic and nonstochastic (or deterministic). The changes in the DNA of the gametes that are classed as genetic mutations are of the stochastic class, as they occur on a probabilistic basis with no threshold for occurrence, and the severity of the phenotypic change resulting from them is unrelated to dose. Two general types of genetically related events can occur as the result of ionizing radiation damage to DNA, including structural changes that are visible in the chromosomes at metaphase, and gene mutations, which are not generally associated with visible structural change in the metaphase chromosomes." @default.
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- W2907174775 date "1998-01-01" @default.
- W2907174775 modified "2023-09-27" @default.
- W2907174775 title "Stochastic Effects — Genetic Effects of Ionizing Radiation" @default.
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- W2907174775 doi "https://doi.org/10.1016/b978-012053085-4/50015-6" @default.
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