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- W2907178631 abstract "Small molecules containing quinone and/or oxime moieties have been found as promising anti-fungal agents. One of them is 4-AN, a recently reported potent anti-Candida compound, which inhibits the formation of hyphae, decreases the level of cellular phosphoproteome, and finally shows no toxicity towards human erythrocytes and zebrafish embryos. Here, further research on 4-AN is presented. The results revealed that the compound: (i) Kills Candida clinical isolates, including these with developed antibiotic resistance, (ii) affects mature biofilm, and (iii) moderately disrupts membrane permeability. Atomic force microscopy studies revealed a slight influence of 4-AN on the cell surface architecture. 4-AN was also shown to inhibit multiple various protein kinases, a characteristic shared by most of the ATP-competitive inhibitors. The presented compound can be used in novel strategies in the fight against candidiasis, and reversible protein phosphorylation should be taken into consideration as a target in designing these strategies." @default.
- W2907178631 created "2019-01-11" @default.
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- W2907178631 date "2019-01-02" @default.
- W2907178631 modified "2023-09-26" @default.
- W2907178631 title "The Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinases" @default.
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- W2907178631 doi "https://doi.org/10.3390/molecules24010153" @default.
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