FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907179907> ?p ?o ?g. }

• W2907179907 endingPage "218" @default.
• W2907179907 startingPage "212" @default.
• W2907179907 abstract "Vestibulo-ocular reflex (VOR) responding to acceleration stimuli is originated from the vestibular apparatuses and thus widely used as an in vivo indicator of the vestibular function. We have developed a vestibular function testing (VFT) system that allows to evaluate VOR response with improved efficiency. The previously required surgical procedure has been avoided by using a newly designed animal-immobility setup. The efficacy of our VFT system was demonstrated on the mice with vestibular abnormalities caused by either genetic mutations (Lhfpl5-/- or Cdh23-/-) or applied vestibulotoxicant (3,3'-iminodipropionitrile, IDPN). Daily longitudinal inspection of the VOR response in the IDPN-administered mice gives the first VOR-based daily-progression profile of the vestibular impairment. The capability of VOR in quantifying the severity of toxicant-induced vestibular deficits has been also demonstrated. The acquired VOR-measurement results were validated against the corresponding behavioral-test results. Further validation against immunofluorescence microscopy was applied to the VOR data obtained from the IDPN-administered mice. We conclude that the improved efficiency of our surgery-free VFT system, firstly, enables the characterization of VOR temporal dynamics and quantification of vestibular-impairment severity that may reveal useful information in toxicological and/or pharmaceutical studies; and, secondly, confers our system promising potential to serve as a high-throughput screener for identifying genes and drugs that affect vestibular function." @default.
• W2907179907 created "2019-01-11" @default.
• W2907179907 creator A5005901099 @default.
• W2907179907 creator A5017600347 @default.
• W2907179907 creator A5020088480 @default.
• W2907179907 creator A5031767581 @default.
• W2907179907 creator A5036245319 @default.
• W2907179907 creator A5047816038 @default.
• W2907179907 creator A5048926024 @default.
• W2907179907 creator A5055984736 @default.
• W2907179907 creator A5056719066 @default.
• W2907179907 creator A5058453644 @default.
• W2907179907 creator A5060264178 @default.
• W2907179907 creator A5068746887 @default.
• W2907179907 creator A5071155877 @default.
• W2907179907 creator A5076628427 @default.
• W2907179907 creator A5085668994 @default.
• W2907179907 creator A5088863133 @default.
• W2907179907 creator A5089760676 @default.
• W2907179907 date "2019-03-01" @default.
• W2907179907 modified "2023-10-17" @default.
• W2907179907 title "Surgery-free video-oculography in mouse models: enabling quantitative and short-interval longitudinal assessment of vestibular function" @default.
• W2907179907 cites W1514414732 @default.
• W2907179907 cites W1969994570 @default.
• W2907179907 cites W1981009482 @default.
• W2907179907 cites W1994142186 @default.
• W2907179907 cites W2019670494 @default.
• W2907179907 cites W2041061246 @default.
• W2907179907 cites W2052287504 @default.
• W2907179907 cites W2052391477 @default.
• W2907179907 cites W2064252714 @default.
• W2907179907 cites W2074693937 @default.
• W2907179907 cites W2090421229 @default.
• W2907179907 cites W2140002606 @default.
• W2907179907 cites W2601419836 @default.
• W2907179907 cites W2888469287 @default.
• W2907179907 doi "https://doi.org/10.1016/j.neulet.2018.12.036" @default.
• W2907179907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30597229" @default.
• W2907179907 hasPublicationYear "2019" @default.
• W2907179907 type Work @default.
• W2907179907 sameAs 2907179907 @default.
• W2907179907 citedByCount "7" @default.
• W2907179907 countsByYear W29071799072020 @default.
• W2907179907 countsByYear W29071799072022 @default.
• W2907179907 countsByYear W29071799072023 @default.
• W2907179907 crossrefType "journal-article" @default.
• W2907179907 hasAuthorship W2907179907A5005901099 @default.
• W2907179907 hasAuthorship W2907179907A5017600347 @default.
• W2907179907 hasAuthorship W2907179907A5020088480 @default.
• W2907179907 hasAuthorship W2907179907A5031767581 @default.
• W2907179907 hasAuthorship W2907179907A5036245319 @default.
• W2907179907 hasAuthorship W2907179907A5047816038 @default.
• W2907179907 hasAuthorship W2907179907A5048926024 @default.
• W2907179907 hasAuthorship W2907179907A5055984736 @default.
• W2907179907 hasAuthorship W2907179907A5056719066 @default.
• W2907179907 hasAuthorship W2907179907A5058453644 @default.
• W2907179907 hasAuthorship W2907179907A5060264178 @default.
• W2907179907 hasAuthorship W2907179907A5068746887 @default.
• W2907179907 hasAuthorship W2907179907A5071155877 @default.
• W2907179907 hasAuthorship W2907179907A5076628427 @default.
• W2907179907 hasAuthorship W2907179907A5085668994 @default.
• W2907179907 hasAuthorship W2907179907A5088863133 @default.
• W2907179907 hasAuthorship W2907179907A5089760676 @default.
• W2907179907 hasConcept C15744967 @default.
• W2907179907 hasConcept C169760540 @default.
• W2907179907 hasConcept C190041318 @default.
• W2907179907 hasConcept C2777340575 @default.
• W2907179907 hasConcept C42219234 @default.
• W2907179907 hasConcept C548259974 @default.
• W2907179907 hasConcept C71924100 @default.
• W2907179907 hasConcept C83974742 @default.
• W2907179907 hasConceptScore W2907179907C15744967 @default.
• W2907179907 hasConceptScore W2907179907C169760540 @default.
• W2907179907 hasConceptScore W2907179907C190041318 @default.
• W2907179907 hasConceptScore W2907179907C2777340575 @default.
• W2907179907 hasConceptScore W2907179907C42219234 @default.
• W2907179907 hasConceptScore W2907179907C548259974 @default.
• W2907179907 hasConceptScore W2907179907C71924100 @default.
• W2907179907 hasConceptScore W2907179907C83974742 @default.
• W2907179907 hasFunder F4320321001 @default.
• W2907179907 hasLocation W29071799071 @default.
• W2907179907 hasLocation W29071799072 @default.
• W2907179907 hasOpenAccess W2907179907 @default.
• W2907179907 hasPrimaryLocation W29071799071 @default.
• W2907179907 hasRelatedWork W1515035751 @default.
• W2907179907 hasRelatedWork W1650592735 @default.
• W2907179907 hasRelatedWork W1966836874 @default.
• W2907179907 hasRelatedWork W199024656 @default.
• W2907179907 hasRelatedWork W1997433060 @default.
• W2907179907 hasRelatedWork W2016283605 @default.
• W2907179907 hasRelatedWork W2023631655 @default.
• W2907179907 hasRelatedWork W2084974407 @default.
• W2907179907 hasRelatedWork W21324351 @default.
• W2907179907 hasRelatedWork W2171731360 @default.
• W2907179907 hasVolume "696" @default.
• W2907179907 isParatext "false" @default.
• W2907179907 isRetracted "false" @default.
• W2907179907 magId "2907179907" @default.

• next