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- W2907202075 abstract "Pulmonary hypertension is a severe condition that can develop during childhood due to several different etiologies. During the last two decades, based on a better understanding of the underlying pathobiology leading to pulmonary arterial hypertension, targeted therapies have been developed and have improved the dreadful prognosis of the condition. However, curative therapy remains elusive. Areas covered: In this article, we will review the currently available drugs in pediatric pulmonary arterial hypertension and discuss the recommended management strategies. Expert commentary: Most of the drugtrials in pulmonary hypertension have been performed in adults, with extrapolation of the results to children. Most of the pediatric studies are non-controlled. The rarity of the disease and the lack of identifiable pediatric treatment goals and satisfactory trial end-points could explain the paucity of specific pediatric studies. An evolution has been made in the last few years regarding the treatment strategy of pulmonary arterial hypertension, with evidence that early combination therapy with at least two pulmonary vasodilators was beneficial on the survival. Children with pulmonary hypertension should be referred to experienced centers early, to benefit from a comprehensive initial assessment. Serial clinical and hemodynamic re-evaluation should assess treatment response and guide potential change in therapy." @default.
- W2907202075 created "2019-01-11" @default.
- W2907202075 creator A5004729513 @default.
- W2907202075 creator A5028548591 @default.
- W2907202075 creator A5052282386 @default.
- W2907202075 date "2019-01-11" @default.
- W2907202075 modified "2023-10-18" @default.
- W2907202075 title "An update on current and emerging treatments for pulmonary arterial hypertension in childhood and adolescence" @default.
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- W2907202075 doi "https://doi.org/10.1080/17476348.2019.1565998" @default.
- W2907202075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30614292" @default.
- W2907202075 hasPublicationYear "2019" @default.
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