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• W2907232886 abstract "Using histamine as lead molecule, a library of (hetero)aryl substituted thiazol-2,4-yl derivatives incorporating pyridine as proton shuttling moiety were obtained and investigated as activators of human carbonic anhydrase (CA, EC 4.2.1.1) isoforms I, II, VII and XIV. Some derivatives displayed good activating and selectivity profiles. This study provides an interesting opportunity to study the thiazole scaffold for the design of CA activators (CAAs), possibly acting on the central nervous system and targeting pathologies involving memory and learning impairments." @default.
• W2907232886 created "2019-01-11" @default.
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• W2907232886 date "2019-01-01" @default.
• W2907232886 modified "2023-10-03" @default.
• W2907232886 title "(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators" @default.
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• W2907232886 doi "https://doi.org/10.1080/14756366.2018.1543292" @default.
• W2907232886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6327990" @default.
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