Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907234809> ?p ?o ?g. }
- W2907234809 endingPage "13704" @default.
- W2907234809 startingPage "13693" @default.
- W2907234809 abstract "Abstract Selenium (Se) deficiency induces typical clinical and pathological changes and causes various pathological responses at the molecular level in several different chicken organs; the kidney is one of the target organs of Se deficiency. To explore the mechanisms that underlie the effects of microRNA‐33‐3p (miR‐33‐3p) on Se deficiency‐induced kidney apoptosis, 60 chickens were randomly divided into two groups (30 chickens per group). We found that Se deficiency increased the expression of miR‐33‐3p in the chicken kidney. A disintegrin and metalloprotease domain 10 (ADAM10) was verified to be a target of miR‐33‐3p in the chicken kidney. The overexpression of miR‐33‐3p decreased the expression levels of β‐catenin, cyclinD1, T‐cell factor (TCF), c‐myc, survivin, and Bcl‐2; it increased the expression levels of E‐cadherin, Bak, Bax, and caspase‐3; and it increased the number of chicken kidney cells in the G0/G1 phase. In addition, Se deficiency caused the ultrastructure of the kidney to develop apoptotic characteristics. The results of flow cytometry analysis and AO/EB staining showed that the number of apoptotic chicken kidney cells increased in the miR‐33‐3p mimic group. All these results suggest that Se deficiency‐induced cell cycle arrest and apoptosis in vivo and in vitro in the chicken kidney via the regulation of miR‐33‐3p, which targets ADAM10." @default.
- W2907234809 created "2019-01-11" @default.
- W2907234809 creator A5001369569 @default.
- W2907234809 creator A5009164181 @default.
- W2907234809 creator A5038854191 @default.
- W2907234809 creator A5052786992 @default.
- W2907234809 creator A5061605734 @default.
- W2907234809 creator A5082075000 @default.
- W2907234809 date "2019-01-03" @default.
- W2907234809 modified "2023-10-11" @default.
- W2907234809 title "microRNA‐33‐3p involved in selenium deficiency‐induced apoptosis via targeting ADAM10 in the chicken kidney" @default.
- W2907234809 cites W1718622617 @default.
- W2907234809 cites W1769406638 @default.
- W2907234809 cites W1973308033 @default.
- W2907234809 cites W1974502663 @default.
- W2907234809 cites W1974962285 @default.
- W2907234809 cites W1993370376 @default.
- W2907234809 cites W1994296787 @default.
- W2907234809 cites W1995361202 @default.
- W2907234809 cites W1995406149 @default.
- W2907234809 cites W1999757871 @default.
- W2907234809 cites W2005101609 @default.
- W2907234809 cites W2012616814 @default.
- W2907234809 cites W2030157806 @default.
- W2907234809 cites W2030354790 @default.
- W2907234809 cites W2036334824 @default.
- W2907234809 cites W2047043150 @default.
- W2907234809 cites W2065341781 @default.
- W2907234809 cites W2068838924 @default.
- W2907234809 cites W2077202176 @default.
- W2907234809 cites W2078973197 @default.
- W2907234809 cites W2086991770 @default.
- W2907234809 cites W2093338540 @default.
- W2907234809 cites W2098318517 @default.
- W2907234809 cites W2112519528 @default.
- W2907234809 cites W2114570899 @default.
- W2907234809 cites W2119430414 @default.
- W2907234809 cites W2121556468 @default.
- W2907234809 cites W2128892894 @default.
- W2907234809 cites W2136763924 @default.
- W2907234809 cites W2137927119 @default.
- W2907234809 cites W2138293552 @default.
- W2907234809 cites W2140573957 @default.
- W2907234809 cites W2148232004 @default.
- W2907234809 cites W2152775147 @default.
- W2907234809 cites W2159167853 @default.
- W2907234809 cites W2164018710 @default.
- W2907234809 cites W2164554101 @default.
- W2907234809 cites W2225772921 @default.
- W2907234809 cites W2245191372 @default.
- W2907234809 cites W2263311874 @default.
- W2907234809 cites W2463552684 @default.
- W2907234809 cites W2589710763 @default.
- W2907234809 cites W2599278292 @default.
- W2907234809 cites W2605791173 @default.
- W2907234809 cites W2620959474 @default.
- W2907234809 cites W2738100812 @default.
- W2907234809 cites W2738211888 @default.
- W2907234809 cites W2771984865 @default.
- W2907234809 cites W2772227821 @default.
- W2907234809 cites W2792667002 @default.
- W2907234809 cites W2805246652 @default.
- W2907234809 cites W2810661498 @default.
- W2907234809 cites W2888309841 @default.
- W2907234809 cites W2891863579 @default.
- W2907234809 cites W3022288079 @default.
- W2907234809 doi "https://doi.org/10.1002/jcp.28050" @default.
- W2907234809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30605240" @default.
- W2907234809 hasPublicationYear "2019" @default.
- W2907234809 type Work @default.
- W2907234809 sameAs 2907234809 @default.
- W2907234809 citedByCount "25" @default.
- W2907234809 countsByYear W29072348092019 @default.
- W2907234809 countsByYear W29072348092020 @default.
- W2907234809 countsByYear W29072348092021 @default.
- W2907234809 countsByYear W29072348092022 @default.
- W2907234809 crossrefType "journal-article" @default.
- W2907234809 hasAuthorship W2907234809A5001369569 @default.
- W2907234809 hasAuthorship W2907234809A5009164181 @default.
- W2907234809 hasAuthorship W2907234809A5038854191 @default.
- W2907234809 hasAuthorship W2907234809A5052786992 @default.
- W2907234809 hasAuthorship W2907234809A5061605734 @default.
- W2907234809 hasAuthorship W2907234809A5082075000 @default.
- W2907234809 hasConcept C104317684 @default.
- W2907234809 hasConcept C109523444 @default.
- W2907234809 hasConcept C126322002 @default.
- W2907234809 hasConcept C134018914 @default.
- W2907234809 hasConcept C145059251 @default.
- W2907234809 hasConcept C153911025 @default.
- W2907234809 hasConcept C16685009 @default.
- W2907234809 hasConcept C190283241 @default.
- W2907234809 hasConcept C2778259572 @default.
- W2907234809 hasConcept C2778715156 @default.
- W2907234809 hasConcept C2780091579 @default.
- W2907234809 hasConcept C29537977 @default.
- W2907234809 hasConcept C502942594 @default.
- W2907234809 hasConcept C553184892 @default.
- W2907234809 hasConcept C55493867 @default.