FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907263739> ?p ?o ?g. }

• W2907263739 abstract "There is limited evidence on the effectiveness and healthcare costs of switching to fingolimod versus another first line injectable therapy (FLIT) in patients with relapsing multiple sclerosis (RMS) who have already been treated with FLIT.The objectives of the study were to assess the annualized relapse rate (ARR), socio-demographic and clinical characteristics, persistence and adherence rates, healthcare resource utilization and cost among patients with RMS who either switch to fingolimod or another FLIT in routine clinical practice.A multicenter, observational, retrospective chart review was conducted across eight clinics in Canada between 1 May 2011 and 30 June 2013. The data was collected from two cohorts: patients who switched to fingolimod and patients who switched to FLIT from a previous FLIT.A total of 124 patients were included in the study: 82 and 42 switched to fingolimod and FLIT, respectively. There were no significant differences in the patient characteristics at the date of switch except for number of previous disease-modifying therapies (DMTs) which was higher in the fingolimod cohort (fingolimod: 1.52; FLIT: 1.10, p < .001). The ARR during the first year of switching was numerically higher in the FLIT cohort compared to the fingolimod cohort (FLIT: 0.9 [95% CI 0.3-1.6]; fingolimod: 0.3 [95% CI 0.1-0.5]). The negative binomial model adjusted for the number of previous DMTs confirmed a statistically significant difference in ARR between the fingolimod and FLIT cohorts at 12 months of follow-up (p = .012). In the fingolimod cohort, 20.7% of patients experienced at least one relapse compared to 38.1% in the FLIT cohort. In both groups, a high proportion of patients (>90%) showed good treatment adherence (≥80% of prescribed doses)." @default.
• W2907263739 created "2019-01-11" @default.
• W2907263739 creator A5008234768 @default.
• W2907263739 creator A5021092653 @default.
• W2907263739 creator A5038453701 @default.
• W2907263739 creator A5048625654 @default.
• W2907263739 creator A5051605203 @default.
• W2907263739 creator A5052436664 @default.
• W2907263739 creator A5059979501 @default.
• W2907263739 creator A5073565971 @default.
• W2907263739 creator A5078592785 @default.
• W2907263739 creator A5014068925 @default.
• W2907263739 date "2019-01-21" @default.
• W2907263739 modified "2023-10-02" @default.
• W2907263739 title "The clinical and cost impact of switching to fingolimod versus other first line injectable disease-modifying therapies in patients with relapsing multiple sclerosis" @default.
• W2907263739 cites W1970963099 @default.
• W2907263739 cites W1984320431 @default.
• W2907263739 cites W1994577620 @default.
• W2907263739 cites W2000445173 @default.
• W2907263739 cites W2004076487 @default.
• W2907263739 cites W2007677302 @default.
• W2907263739 cites W2023555055 @default.
• W2907263739 cites W2041978490 @default.
• W2907263739 cites W2053836109 @default.
• W2907263739 cites W2067338532 @default.
• W2907263739 cites W2072173083 @default.
• W2907263739 cites W2106769294 @default.
• W2907263739 cites W2112165124 @default.
• W2907263739 cites W2134332800 @default.
• W2907263739 cites W2136686242 @default.
• W2907263739 cites W2137069829 @default.
• W2907263739 cites W2138393161 @default.
• W2907263739 cites W2140240975 @default.
• W2907263739 cites W2140581746 @default.
• W2907263739 cites W2150802886 @default.
• W2907263739 cites W2156268561 @default.
• W2907263739 cites W2193056371 @default.
• W2907263739 cites W2397308456 @default.
• W2907263739 cites W2567289819 @default.
• W2907263739 cites W2587758605 @default.
• W2907263739 cites W2610990451 @default.
• W2907263739 cites W2780926505 @default.
• W2907263739 cites W2794568554 @default.
• W2907263739 cites W2807755883 @default.
• W2907263739 cites W2916040650 @default.
• W2907263739 doi "https://doi.org/10.1080/03007995.2019.1565818" @default.
• W2907263739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30614288" @default.
• W2907263739 hasPublicationYear "2019" @default.
• W2907263739 type Work @default.
• W2907263739 sameAs 2907263739 @default.
• W2907263739 citedByCount "1" @default.
• W2907263739 countsByYear W29072637392020 @default.
• W2907263739 crossrefType "journal-article" @default.
• W2907263739 hasAuthorship W2907263739A5008234768 @default.
• W2907263739 hasAuthorship W2907263739A5014068925 @default.
• W2907263739 hasAuthorship W2907263739A5021092653 @default.
• W2907263739 hasAuthorship W2907263739A5038453701 @default.
• W2907263739 hasAuthorship W2907263739A5048625654 @default.
• W2907263739 hasAuthorship W2907263739A5051605203 @default.
• W2907263739 hasAuthorship W2907263739A5052436664 @default.
• W2907263739 hasAuthorship W2907263739A5059979501 @default.
• W2907263739 hasAuthorship W2907263739A5073565971 @default.
• W2907263739 hasAuthorship W2907263739A5078592785 @default.
• W2907263739 hasConcept C118552586 @default.
• W2907263739 hasConcept C126322002 @default.
• W2907263739 hasConcept C167135981 @default.
• W2907263739 hasConcept C201903717 @default.
• W2907263739 hasConcept C2776036978 @default.
• W2907263739 hasConcept C2780640218 @default.
• W2907263739 hasConcept C71924100 @default.
• W2907263739 hasConcept C72563966 @default.
• W2907263739 hasConceptScore W2907263739C118552586 @default.
• W2907263739 hasConceptScore W2907263739C126322002 @default.
• W2907263739 hasConceptScore W2907263739C167135981 @default.
• W2907263739 hasConceptScore W2907263739C201903717 @default.
• W2907263739 hasConceptScore W2907263739C2776036978 @default.
• W2907263739 hasConceptScore W2907263739C2780640218 @default.
• W2907263739 hasConceptScore W2907263739C71924100 @default.
• W2907263739 hasConceptScore W2907263739C72563966 @default.
• W2907263739 hasLocation W29072637391 @default.
• W2907263739 hasLocation W29072637392 @default.
• W2907263739 hasOpenAccess W2907263739 @default.
• W2907263739 hasPrimaryLocation W29072637391 @default.
• W2907263739 hasRelatedWork W1971557041 @default.
• W2907263739 hasRelatedWork W2005100134 @default.
• W2907263739 hasRelatedWork W2157077459 @default.
• W2907263739 hasRelatedWork W2607162641 @default.
• W2907263739 hasRelatedWork W2677724969 @default.
• W2907263739 hasRelatedWork W2747950348 @default.
• W2907263739 hasRelatedWork W2887090343 @default.
• W2907263739 hasRelatedWork W3090437562 @default.
• W2907263739 hasRelatedWork W4280544775 @default.
• W2907263739 hasRelatedWork W4280590782 @default.
• W2907263739 isParatext "false" @default.
• W2907263739 isRetracted "false" @default.
• W2907263739 magId "2907263739" @default.
• W2907263739 workType "article" @default.