Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907265183> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2907265183 endingPage "4863" @default.
- W2907265183 startingPage "4863" @default.
- W2907265183 abstract "4863 Prevalent changes that occur with the progression of brain tumors include activation of survival pathways and a number of adaptive changes that incorporate a metabolic shift that promote activation of glycolysis, preferentially. Additionally, poorly perfused tumors that become regionally hypoxic also stimulate signaling pathways to up-regulate angiogenesis and shift metabolism to preferentially utilize glycolysis. We postulated that because of these features, gliomas represent a unique disease state that will be particularly sensitive to inhibitors of glycolysis that can deprive tumor cells of glucose derived energy and induce autophagy. To test this hypothesis we have used 2-deoxy-D-glucose (2-DG), a known glycolytic inhibitor, against a number of glioma cell line panels in vitro in both hypoxic and normoxic conditions. 2-DG inhibited glioblastoma cells grown under both conditions at 2-6 mM; these concentrationsare achievable in vivo. Most interestingly, 2-DG potently induces autophagic cell death at 2 mM concentrations in two tested gliomblastoma cell lines (U87 and D54). Subsequently, animals containing orthotopic glioma xenografts were used in dose response studies to confirm, in vivo, activity we observed in vitro. Our studies demonstrated that 2-DG administered orally demonstrated significant antitumor activity. Surprisingly, 2-DG was equally effective in animal survival gains as the positive control used, temozolomide, a drug which is a standard care therapy for brain tumors. This therapy was also well tolerated in vivo with animals showing no evidence of toxicity. These findings are very promising and warrant further preclinical evaluation of 2-DG as well as studies aimed at the design and synthesis of new inhibitors of glycolysis." @default.
- W2907265183 created "2019-01-11" @default.
- W2907265183 creator A5026241338 @default.
- W2907265183 creator A5042163535 @default.
- W2907265183 creator A5053875415 @default.
- W2907265183 creator A5055645760 @default.
- W2907265183 creator A5062959791 @default.
- W2907265183 creator A5086839893 @default.
- W2907265183 creator A5014375026 @default.
- W2907265183 date "2007-05-01" @default.
- W2907265183 modified "2023-09-27" @default.
- W2907265183 title "2-Deoxy-D-glucose: Old molecule, new brain tumor agent inducing autophagy" @default.
- W2907265183 hasPublicationYear "2007" @default.
- W2907265183 type Work @default.
- W2907265183 sameAs 2907265183 @default.
- W2907265183 citedByCount "0" @default.
- W2907265183 crossrefType "journal-article" @default.
- W2907265183 hasAuthorship W2907265183A5014375026 @default.
- W2907265183 hasAuthorship W2907265183A5026241338 @default.
- W2907265183 hasAuthorship W2907265183A5042163535 @default.
- W2907265183 hasAuthorship W2907265183A5053875415 @default.
- W2907265183 hasAuthorship W2907265183A5055645760 @default.
- W2907265183 hasAuthorship W2907265183A5062959791 @default.
- W2907265183 hasAuthorship W2907265183A5086839893 @default.
- W2907265183 hasConcept C150903083 @default.
- W2907265183 hasConcept C190283241 @default.
- W2907265183 hasConcept C20251656 @default.
- W2907265183 hasConcept C203522944 @default.
- W2907265183 hasConcept C207001950 @default.
- W2907265183 hasConcept C2777389519 @default.
- W2907265183 hasConcept C2778227246 @default.
- W2907265183 hasConcept C2780394083 @default.
- W2907265183 hasConcept C502942594 @default.
- W2907265183 hasConcept C54355233 @default.
- W2907265183 hasConcept C55493867 @default.
- W2907265183 hasConcept C62231903 @default.
- W2907265183 hasConcept C71924100 @default.
- W2907265183 hasConcept C81885089 @default.
- W2907265183 hasConcept C86803240 @default.
- W2907265183 hasConcept C98274493 @default.
- W2907265183 hasConceptScore W2907265183C150903083 @default.
- W2907265183 hasConceptScore W2907265183C190283241 @default.
- W2907265183 hasConceptScore W2907265183C20251656 @default.
- W2907265183 hasConceptScore W2907265183C203522944 @default.
- W2907265183 hasConceptScore W2907265183C207001950 @default.
- W2907265183 hasConceptScore W2907265183C2777389519 @default.
- W2907265183 hasConceptScore W2907265183C2778227246 @default.
- W2907265183 hasConceptScore W2907265183C2780394083 @default.
- W2907265183 hasConceptScore W2907265183C502942594 @default.
- W2907265183 hasConceptScore W2907265183C54355233 @default.
- W2907265183 hasConceptScore W2907265183C55493867 @default.
- W2907265183 hasConceptScore W2907265183C62231903 @default.
- W2907265183 hasConceptScore W2907265183C71924100 @default.
- W2907265183 hasConceptScore W2907265183C81885089 @default.
- W2907265183 hasConceptScore W2907265183C86803240 @default.
- W2907265183 hasConceptScore W2907265183C98274493 @default.
- W2907265183 hasLocation W29072651831 @default.
- W2907265183 hasOpenAccess W2907265183 @default.
- W2907265183 hasPrimaryLocation W29072651831 @default.
- W2907265183 hasRelatedWork W1163571799 @default.
- W2907265183 hasRelatedWork W1548043139 @default.
- W2907265183 hasRelatedWork W1981156482 @default.
- W2907265183 hasRelatedWork W2030368798 @default.
- W2907265183 hasRelatedWork W2045938596 @default.
- W2907265183 hasRelatedWork W2062223094 @default.
- W2907265183 hasRelatedWork W2081724546 @default.
- W2907265183 hasRelatedWork W2278613137 @default.
- W2907265183 hasRelatedWork W2295923651 @default.
- W2907265183 hasRelatedWork W2334905784 @default.
- W2907265183 hasRelatedWork W2346516822 @default.
- W2907265183 hasRelatedWork W2430866285 @default.
- W2907265183 hasRelatedWork W2517130978 @default.
- W2907265183 hasRelatedWork W2766236308 @default.
- W2907265183 hasRelatedWork W2792232264 @default.
- W2907265183 hasRelatedWork W2900025852 @default.
- W2907265183 hasRelatedWork W2911925706 @default.
- W2907265183 hasRelatedWork W2974981893 @default.
- W2907265183 hasRelatedWork W3009188812 @default.
- W2907265183 hasRelatedWork W3180832797 @default.
- W2907265183 hasVolume "67" @default.
- W2907265183 isParatext "false" @default.
- W2907265183 isRetracted "false" @default.
- W2907265183 magId "2907265183" @default.
- W2907265183 workType "article" @default.