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- W2907303552 abstract "Introduction: Retroperitoneal sarcoma is a rare tumour that does not present nor progress in a mannertypical for other soft tissue sarcomas. As a result of this the conventional AJCC staging manual forperipheral STSs is not applicable to RPS and does not allow for stratification of patient groups. This hasbeen recognised by other research groups and has led to their development of nomograms, incorporatingstatistically significant clinical characteristics on retrospective multivariate analysis of patient cohorts. Weapplied two of these nomograms to the North East England (NEE) RPS database.Methods: Nomograms published by Gronchi et al. (to predict 7 year overall and disease-free survival) andAnaya et al. (to predict 3 year and 5-year overall survival) were applied retrospectively to the 79 patients inthe NEE RPS database. Statistical analysis was performed by use of concordance index to assess capacityto correctly predict an expected outcome.Results: The nomogram for predicting 3-year OS published by Anaya et al. gave a concordance index of0.792 (95% CI 0.70-0.89), p-value <0.001. For 5-year OS, the model has a concordance index of 0.803(95% CI 0.70 - 0.91), p-value <0.001. The nomogram published by Gronchi et al. to predict 7-year OS wasalso applied to our cohort and produced a concordance index of 0.539 (95% CI 0.34-0.74), p value 0.70. Nopatients in our cohort were disease free at 7 years and so analysis could not be performed.Conclusion: The nomogram published by Gronchi et al. was not able to accurately predict the seven-yearsurvival outcome for patients in the NEE RPS database however the nomogram published by Anaya et al.provided an accurate prediction of 3 and 5 year survival in our cohort. This warrants further externalvalidation of this cohort using a larger cohort and incorporating a version of this nomogram into the nextedition of the AJCC Staging Manual should be considered." @default.
- W2907303552 created "2019-01-11" @default.
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- W2907303552 date "2018-10-13" @default.
- W2907303552 modified "2023-10-18" @default.
- W2907303552 title "External validation of nomograms for prediction of survival outcome in retroperitoneal sarcoma using the North East England patient cohort" @default.
- W2907303552 doi "https://doi.org/10.31487/j.cor.2018.03.106" @default.
- W2907303552 hasPublicationYear "2018" @default.
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