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- W2907331357 endingPage "10272" @default.
- W2907331357 startingPage "10248" @default.
- W2907331357 abstract "The phosphatidylinositol 3-kinases (PI3K)/Akt signaling pathway is one of the well-characterized and most important signaling pathways activated in response to DNA damage. This review discusses the most recent discoveries on the involvement of PI3K/Akt signaling pathway in cancer development, as well as stimulation of some important signaling networks involved in the maintenance of cellular homeostasis upon DNA damage, with an exploration of how PI3K/Akt signaling pathway contributes to the regulation of modulators and effectors underlying DNA damage response, the intricate, protein-based signal transduction network, which decides between cell cycle arrest, DNA repair, and apoptosis, the elimination of irreparably damaged cells to maintain homeostasis. The review continues by looking at the interplay between cell cycle checkpoints, checking the repair of damage inflicted to the DNA before entering DNA replication to facilitate DNA synthesis, and PI3K/Akt signaling pathway. We then investigate the challenges the cells overcome to ameliorate damages induced by oxidative activities, for example, the recruitment of many pathways and factors to maintain integrity and hemostasis. Finally, the review provides a discussion of how cells use the PI3K/Akt signaling pathway to regulate the balance between these networks." @default.
- W2907331357 created "2019-01-11" @default.
- W2907331357 creator A5013984930 @default.
- W2907331357 creator A5016497111 @default.
- W2907331357 creator A5017660016 @default.
- W2907331357 creator A5036672079 @default.
- W2907331357 creator A5050090015 @default.
- W2907331357 creator A5068512569 @default.
- W2907331357 creator A5087439089 @default.
- W2907331357 date "2018-12-28" @default.
- W2907331357 modified "2023-10-18" @default.
- W2907331357 title "Crosstalk between Phosphoinositide 3‐kinase/Akt signaling pathway with DNA damage response and oxidative stress in cancer" @default.
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