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• W2907384324 abstract "Background: Due to the prevalence of Hepatocellular carcinoma (HCC) in Saudi Arabia, using new markers togive best diagnostic performance than alpha-feto protein (AFP) are important in early diagnosis. The aim of this workwas to compare the significance between serum and mRNA Golgi glypican73 (GP-73) as newly identified diagnosticand prognostic markers for HCC among Saudi patients. Materials and Methods: A total of 300 subjects were dividedinto: 250 blood samples where 145 samples from HCC, 105 samples from chronic liver cirrhosis (CLC) and 50 normalcontrols were investigated for serum GP73 (sGP73) by ELISA. GP-73 mRNA from peripheral blood mononuclear cellswas amplified by RT-PCR. The sensitivity and specificity of both techniques was compared. Results: Serum Golgiglypican 73 was significantly higher in HCC group compared to cirrhotic and normal controls (p<0.001). Sensitivityand specificity were 95% for sGP-73, 100% and 90% for Golgi glypican 73 mRNA. The combination of sensitivitybetween AFP and sGP73 was 80% and 95% respectively. Conclusion: Both serum Golgi glypican-73 and GP-73Mrnaare good diagnostic biomarkers for early detection of HCC in Saudi patients. RT-PCR is more accurate and sensitive(100%) than ELISA (95%) in detecting Golgi glypican 73." @default.
• W2907384324 created "2019-01-11" @default.
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• W2907384324 date "2019-01-01" @default.
• W2907384324 modified "2023-10-14" @default.
• W2907384324 title "Studying the Impact of Golgi Glypican73 Serving as a Candidate Biomarker in Early Diagnosis for Hepatocellular Carcinoma among Saudi Patients" @default.
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• W2907384324 doi "https://doi.org/10.31557/apjcp.2019.20.1.215" @default.
• W2907384324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6485586" @default.
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