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- W2907401464 abstract "The requirement of platelets for experimental pulmonary metastasis and the ability of tumor cells to aggregate platelets was first recognized by Gasic and coworkers in 1968, who demonstrated impaired experimental pulmonary metastasis in mice following platelet depletion.1 These observations prompted numerous studies that have demonstrated a role for platelets in the hematogenous dissemination of animal tumors: many tumor cells require platelets for the development of metastasis;1-5 ultrastructural studies have demonstrated arrested tumor emboli surrounded by platelets; 6-9 several tumor cells induce thrombocytopenia in vivo1-3 and aggregate platelets in vitro; 2,4,10-18 and a correlation exists between the ability of some tumor cells to aggregate platelets in vitro and their requirement for metastasis in vivo . 2,4" @default.
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- W2907401464 date "2007-01-01" @default.
- W2907401464 modified "2023-09-24" @default.
- W2907401464 title "Tumor Growth and Metastasis" @default.
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- W2907401464 doi "https://doi.org/10.1016/b978-012369367-9/50804-1" @default.
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