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- W2907444528 abstract "Introduction: While arsenic is a known human carcinogen as well as associated with a number of other adverse health outcomes, its mechanism of toxicity remains unknown. Aberrant epigenetic and gene expression pathways have been suggested to underlie arsenic toxicity; however, molecular epidemiological studies of arsenic exposure are still sparse. Therefore, among a sample of 400 adult participants in the Bangladesh Vitamin E and Selenium Trial, we evaluated the association between arsenic exposure and epigenome-wide DNA methylation and genome-wide gene expression in cross-sectional analyses. Methods: BEST participants, aged 25-65 years at enrollment, have been chronically exposed to naturally-occurring arsenic through the consumption of groundwater. Individual-level arsenic exposure was measured by urinary total arsenic and blood arsenic concentrations. DNA methylation status was assessed from whole blood DNA using the Illumina Infinium HumanMethylation450 BeadChip, which measures methylation of =485,000 CpG sites. Gene expression was assessed from peripheral blood mononuclear cell RNA using the Illumina HumanHT-12 v4 Expression BeadChip, which measures expression of =47,000 mRNA transcripts. Linear regression models were used to examine the associations between arsenic with each CpG site or mRNA transcript, adjusted for sex, age, and batch. Bonferroni correction was applied to the level of significance to account for multiple comparisons. Results: In adjusted analyses, we observed several significantly differentially methylated CpG sites as well as differentially expressed genes in relation to arsenic exposure. Through integrated analyses, we additionally identified a subset of genes, which showed evidence of gene regulation through epigenetic mechanisms in relation to arsenic exposure. Conclusion: Our findings indicate novel genes and pathways that may be associated with arsenic toxicity and should be examined in relation to risk of arsenic-related diseases." @default.
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- W2907444528 date "2015-08-20" @default.
- W2907444528 modified "2023-09-26" @default.
- W2907444528 title "Epigenetic And Gene Expression Effects Of Arsenic Exposure" @default.
- W2907444528 doi "https://doi.org/10.1289/isee.2015.2015-221" @default.
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