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• W2907478003 abstract "Comprehensive genomic profiling for non-small cell lung cancer (NSCLC) is likely to identify more patients with rare genetic alterations, including uncommon epidermal growth factor receptor (EGFR) gene mutation.A 63-year-old Chinese woman who had never smoked visited our lung cancer clinic due to a chronic cough.The patient was diagnosed with lung adenocarcinoma by transbronchial lung biopsy. An EGFR mutation (exon 20 insertion H773_V774insH, D770_N771insG, V769_D770insASV, D770_N771insSVD) was detected in the biopsy specimen by quantitative real-time PCR.The patient was treated with osimertinib first, and the progression-free survival (PFS) was 4.4 months. After the disease progressed, the second genetic test of pleural effusion suggesting the EGFR exon 20-ins mutation site changed to A767delinsASVD only. Then the patient was treated with afatinib with informed consent.The treatment of afatinib in this patient was successful, PFS was 7.4 months.To our knowledge, EGFR exon 20-ins mutation A767delinsASVD has never been reported, and the successful treatment of afatinib may provide a new therapeutic option for this type of exon 20 insertion mutations." @default.
• W2907478003 created "2019-01-11" @default.
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• W2907478003 date "2019-01-01" @default.
• W2907478003 modified "2023-09-26" @default.
• W2907478003 title "Successful treatment of a lung adenocarcinoma patient with a novel EGFR exon 20-ins mutation with afatinib" @default.
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• W2907478003 doi "https://doi.org/10.1097/md.0000000000013890" @default.
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