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• W2907509292 abstract "Nanoparticles (NPs) have been used as contrast agents for several bioimaging modalities. X-ray fluorescence (XRF) tomography can provide sensitive and quantitative 3D detection of NPs. With spectrally matched NPs as contrast agents, we demonstrated earlier in a laboratory system that XRF tomography could achieve high-spatial-resolution tumor imaging in mice. Here, we present the synthesis, characterization, and evaluation of a library of NPs containing Y, Zr, Nb, Rh, and Ru that have spectrally matched K-shell absorption for the laboratory scale X-ray source. The K-shell emissions of these NPs are spectrally well separated from the X-ray probe and the Compton background, making them suitable for the lab-scale XRF tomography system. Their potential as XRF contrast agents is demonstrated successfully in a small-animal equivalent phantom, confirming the simulation results. The diversity in the NP composition provides a flexible platform for a better design and biological optimization of XRF tomography nanoprobes." @default.
• W2907509292 created "2019-01-11" @default.
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• W2907509292 date "2018-12-27" @default.
• W2907509292 modified "2023-10-18" @default.
• W2907509292 title "A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging" @default.
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• W2907509292 doi "https://doi.org/10.1155/2018/8174820" @default.
• W2907509292 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6327276" @default.
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