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- W2907525610 abstract "The cytolysin toxin, produced by the Gram-positive bacterium Enterococcus faecalis, is unique among bacterial toxins in its ability to lyse both bacterial cells and eukaryotic cells. This chapter describes what is known about the range of target cells, the molecular determinants of cytolysin activity, the mobility of the cytolysin-encoding locus, regulation of the expression of cytolysin activity, and the role of cytolysin in enterococcal virulence. The cytolysin toxin of E.faecalis is a two-subunit hemolysin and bacteriocin capable of lysing a broad range of target cells. The maturation process of the two structural toxin subunits is similar to the maturation process of other lantibiotic bacteriocins, but the regulatory activity of each of these subunits in calibrating toxin expression to reflect cell density and the presence of target cells is novel. Further studies of the components of the cytolysin locus and the target celltoxin interactions are certain to yield more interesting mechanisms and may inform the development of a therapeutic agent to neutralize this virulence factor." @default.
- W2907525610 created "2019-01-11" @default.
- W2907525610 creator A5057107293 @default.
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- W2907525610 date "2006-01-01" @default.
- W2907525610 modified "2023-09-27" @default.
- W2907525610 title "Enterococcus faecalis cytolysin toxin" @default.
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- W2907525610 doi "https://doi.org/10.1016/b978-012088445-2/50046-9" @default.
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