FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907599368> ?p ?o ?g. }

• W2907599368 endingPage "2" @default.
• W2907599368 startingPage "2" @default.
• W2907599368 abstract "Staphylococcus aureus is a major cause of corneal infections that can cause reduced vision, even blindness. Secreted toxins cause tissue damage and inflammation resulting in scars that lead to vision loss. Identifying tissue damaging proteins is a prerequisite to limiting these harmful reactions. The present study characterized a previously unrecognized S. aureus toxin. This secreted toxin was purified from strain Newman ΔhlaΔhlg, the N-terminal sequence determined, the gene cloned, and the purified recombinant protein was tested in the rabbit cornea. The virulence of a toxin deletion mutant was compared to its parent and the mutant after gene restoration (rescue strain). The toxin (23 kDa) had an N-terminal sequence matching the Newman superantigen-like protein SSL1. An SSL1 homodimer (46 kDa) had proteolytic activity as demonstrated by zymography and cleavage of a synthetic substrate, collagens, and cytokines (IL-17A, IFN-γ, and IL-8); the protease was susceptible to serine protease inhibitors. As compared to the parent and rescue strains, the ssl1 mutant had significantly reduced virulence, but not reduced bacterial growth, in vivo. The ocular isolates tested had the ssl1 gene, with allele type 2 being the predominant type. SSL1 is a protease with corneal virulence and activity on host defense and structural proteins." @default.
• W2907599368 created "2019-01-11" @default.
• W2907599368 creator A5003945619 @default.
• W2907599368 creator A5006451887 @default.
• W2907599368 creator A5017416740 @default.
• W2907599368 creator A5022538276 @default.
• W2907599368 creator A5036656088 @default.
• W2907599368 creator A5060987065 @default.
• W2907599368 creator A5080979214 @default.
• W2907599368 date "2019-01-01" @default.
• W2907599368 modified "2023-09-28" @default.
• W2907599368 title "Staphylococcus aureus Superantigen-Like Protein SSL1: A Toxic Protease" @default.
• W2907599368 cites W116426194 @default.
• W2907599368 cites W1624721229 @default.
• W2907599368 cites W1826935712 @default.
• W2907599368 cites W1878404532 @default.
• W2907599368 cites W1959518502 @default.
• W2907599368 cites W1969336599 @default.
• W2907599368 cites W1982285611 @default.
• W2907599368 cites W1982574976 @default.
• W2907599368 cites W2021954232 @default.
• W2907599368 cites W2031317540 @default.
• W2907599368 cites W2034959804 @default.
• W2907599368 cites W2035544684 @default.
• W2907599368 cites W2046801743 @default.
• W2907599368 cites W2063456308 @default.
• W2907599368 cites W2066137456 @default.
• W2907599368 cites W2076824876 @default.
• W2907599368 cites W2080358616 @default.
• W2907599368 cites W2090544282 @default.
• W2907599368 cites W2092631613 @default.
• W2907599368 cites W2093172141 @default.
• W2907599368 cites W2101748249 @default.
• W2907599368 cites W2104907221 @default.
• W2907599368 cites W2106704463 @default.
• W2907599368 cites W2110763275 @default.
• W2907599368 cites W2113888104 @default.
• W2907599368 cites W2122733482 @default.
• W2907599368 cites W2124995859 @default.
• W2907599368 cites W2131406530 @default.
• W2907599368 cites W2133095398 @default.
• W2907599368 cites W2134066586 @default.
• W2907599368 cites W2137180044 @default.
• W2907599368 cites W2144587217 @default.
• W2907599368 cites W2146696708 @default.
• W2907599368 cites W2146802311 @default.
• W2907599368 cites W2147810945 @default.
• W2907599368 cites W2151669381 @default.
• W2907599368 cites W2169665400 @default.
• W2907599368 cites W2179818990 @default.
• W2907599368 cites W2321613997 @default.
• W2907599368 cites W2466711967 @default.
• W2907599368 cites W2783103219 @default.
• W2907599368 cites W34158357 @default.
• W2907599368 cites W4211016618 @default.
• W2907599368 doi "https://doi.org/10.3390/pathogens8010002" @default.
• W2907599368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6471365" @default.
• W2907599368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30609641" @default.
• W2907599368 hasPublicationYear "2019" @default.
• W2907599368 type Work @default.
• W2907599368 sameAs 2907599368 @default.
• W2907599368 citedByCount "9" @default.
• W2907599368 countsByYear W29075993682019 @default.
• W2907599368 countsByYear W29075993682021 @default.
• W2907599368 countsByYear W29075993682022 @default.
• W2907599368 countsByYear W29075993682023 @default.
• W2907599368 crossrefType "journal-article" @default.
• W2907599368 hasAuthorship W2907599368A5003945619 @default.
• W2907599368 hasAuthorship W2907599368A5006451887 @default.
• W2907599368 hasAuthorship W2907599368A5017416740 @default.
• W2907599368 hasAuthorship W2907599368A5022538276 @default.
• W2907599368 hasAuthorship W2907599368A5036656088 @default.
• W2907599368 hasAuthorship W2907599368A5060987065 @default.
• W2907599368 hasAuthorship W2907599368A5080979214 @default.
• W2907599368 hasBestOaLocation W29075993681 @default.
• W2907599368 hasConcept C104317684 @default.
• W2907599368 hasConcept C143065580 @default.
• W2907599368 hasConcept C153911025 @default.
• W2907599368 hasConcept C181199279 @default.
• W2907599368 hasConcept C182220744 @default.
• W2907599368 hasConcept C2776714187 @default.
• W2907599368 hasConcept C2777367657 @default.
• W2907599368 hasConcept C2777807008 @default.
• W2907599368 hasConcept C2779489039 @default.
• W2907599368 hasConcept C2781090273 @default.
• W2907599368 hasConcept C523546767 @default.
• W2907599368 hasConcept C54355233 @default.
• W2907599368 hasConcept C55493867 @default.
• W2907599368 hasConcept C60987743 @default.
• W2907599368 hasConcept C86803240 @default.
• W2907599368 hasConcept C89423630 @default.
• W2907599368 hasConceptScore W2907599368C104317684 @default.
• W2907599368 hasConceptScore W2907599368C143065580 @default.
• W2907599368 hasConceptScore W2907599368C153911025 @default.
• W2907599368 hasConceptScore W2907599368C181199279 @default.
• W2907599368 hasConceptScore W2907599368C182220744 @default.
• W2907599368 hasConceptScore W2907599368C2776714187 @default.
• W2907599368 hasConceptScore W2907599368C2777367657 @default.

• next