FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907607280> ?p ?o ?g. }

• W2907607280 endingPage "101" @default.
• W2907607280 startingPage "93" @default.
• W2907607280 abstract "Glioblastoma multiforme (GBM) has few clinically approved therapeutic regimens. One of these therapeutic options includes placing biodegradable wafers releasing BCNU (Gliadel®) into the tumor bed at the time of surgical removal of the tumor. Due to the significant benefit this polymer technology has had clinically, we have prepared wafers releasing Temozolomide (TMZ), an anticancer drug used systemically for treating GBM. TMZ delivered via polymer wafer could be used as a complementary treatment with or as an alternative to Gliadel®. TMZ is an alkylating agent which is water soluble. To remain comparable with the preclinical studies that led to Gliadel® the same size of wafers were formulated with TMZ. Wafers were loaded with 50% w/w TMZ in poly(lactic acid-glycolic acid) (PLGA) and showed reliable release of high dose TMZ for a period of 4 weeks. To achieve this 30-day release of the highly water soluble drug, we developed an encapsulation method, where the drug powder was first coated with the polymer to form core-shell particles in which the coating shell served as a rate controlling membrane for the drug particles. Wafers were also made with a co-loading of TMZ and BCNU. All wafers were tested in vivo by treating an intracranial 9 L gliosarcoma model in F344 rats. Rats that were either untreated or treated with blank wafer died within 11 days while the median survival for rats treated with systemic TMZ was 18 days. The group that received the BCNU alone wafer had a median survival of 15 days, the group that received the TMZ wafer alone had a median survival of 19 days, and the group treated with the BCNU-TMZ wafer had a median survival of 28 days with 25% of the animals living long term (p < .0038 vs. Control; p < .001 vs. Blank Polymer). These findings demonstrate the potential of this newly designed wafer for treating GBM. Moreover, this concept, can pave the way for other drug combinations that may improve the clinical application of numerous agents to treat solid tumors." @default.
• W2907607280 created "2019-01-11" @default.
• W2907607280 creator A5010219978 @default.
• W2907607280 creator A5017054260 @default.
• W2907607280 creator A5031555106 @default.
• W2907607280 creator A5038810448 @default.
• W2907607280 creator A5042597057 @default.
• W2907607280 creator A5049334243 @default.
• W2907607280 creator A5054184933 @default.
• W2907607280 creator A5055192528 @default.
• W2907607280 creator A5060287350 @default.
• W2907607280 creator A5064814225 @default.
• W2907607280 creator A5071726618 @default.
• W2907607280 creator A5073336340 @default.
• W2907607280 creator A5082351363 @default.
• W2907607280 date "2019-02-01" @default.
• W2907607280 modified "2023-10-18" @default.
• W2907607280 title "Biodegradable wafers releasing Temozolomide and Carmustine for the treatment of brain cancer" @default.
• W2907607280 cites W1570195799 @default.
• W2907607280 cites W1910239081 @default.
• W2907607280 cites W1966720603 @default.
• W2907607280 cites W1974000574 @default.
• W2907607280 cites W1976535263 @default.
• W2907607280 cites W1976642420 @default.
• W2907607280 cites W1978623042 @default.
• W2907607280 cites W1981284405 @default.
• W2907607280 cites W2002386579 @default.
• W2907607280 cites W2015100338 @default.
• W2907607280 cites W2032090704 @default.
• W2907607280 cites W2033329981 @default.
• W2907607280 cites W2038163024 @default.
• W2907607280 cites W2044013857 @default.
• W2907607280 cites W2045449837 @default.
• W2907607280 cites W2056700668 @default.
• W2907607280 cites W2056730157 @default.
• W2907607280 cites W2059366293 @default.
• W2907607280 cites W2063553452 @default.
• W2907607280 cites W2077672491 @default.
• W2907607280 cites W2079786467 @default.
• W2907607280 cites W2087032263 @default.
• W2907607280 cites W2091857781 @default.
• W2907607280 cites W2096287682 @default.
• W2907607280 cites W2100567246 @default.
• W2907607280 cites W2111835079 @default.
• W2907607280 cites W2114873155 @default.
• W2907607280 cites W2124696441 @default.
• W2907607280 cites W2149145595 @default.
• W2907607280 cites W2164385994 @default.
• W2907607280 cites W2164675211 @default.
• W2907607280 cites W2331750420 @default.
• W2907607280 cites W2416606407 @default.
• W2907607280 cites W2508896552 @default.
• W2907607280 cites W2546146433 @default.
• W2907607280 cites W2569483068 @default.
• W2907607280 cites W2595147197 @default.
• W2907607280 cites W2620951925 @default.
• W2907607280 cites W2719234611 @default.
• W2907607280 cites W2756347167 @default.
• W2907607280 doi "https://doi.org/10.1016/j.jconrel.2018.12.048" @default.
• W2907607280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30605703" @default.
• W2907607280 hasPublicationYear "2019" @default.
• W2907607280 type Work @default.
• W2907607280 sameAs 2907607280 @default.
• W2907607280 citedByCount "63" @default.
• W2907607280 countsByYear W29076072802019 @default.
• W2907607280 countsByYear W29076072802020 @default.
• W2907607280 countsByYear W29076072802021 @default.
• W2907607280 countsByYear W29076072802022 @default.
• W2907607280 countsByYear W29076072802023 @default.
• W2907607280 crossrefType "journal-article" @default.
• W2907607280 hasAuthorship W2907607280A5010219978 @default.
• W2907607280 hasAuthorship W2907607280A5017054260 @default.
• W2907607280 hasAuthorship W2907607280A5031555106 @default.
• W2907607280 hasAuthorship W2907607280A5038810448 @default.
• W2907607280 hasAuthorship W2907607280A5042597057 @default.
• W2907607280 hasAuthorship W2907607280A5049334243 @default.
• W2907607280 hasAuthorship W2907607280A5054184933 @default.
• W2907607280 hasAuthorship W2907607280A5055192528 @default.
• W2907607280 hasAuthorship W2907607280A5060287350 @default.
• W2907607280 hasAuthorship W2907607280A5064814225 @default.
• W2907607280 hasAuthorship W2907607280A5071726618 @default.
• W2907607280 hasAuthorship W2907607280A5073336340 @default.
• W2907607280 hasAuthorship W2907607280A5082351363 @default.
• W2907607280 hasConcept C136229726 @default.
• W2907607280 hasConcept C141071460 @default.
• W2907607280 hasConcept C150903083 @default.
• W2907607280 hasConcept C155672457 @default.
• W2907607280 hasConcept C159985019 @default.
• W2907607280 hasConcept C171250308 @default.
• W2907607280 hasConcept C192562407 @default.
• W2907607280 hasConcept C207001950 @default.
• W2907607280 hasConcept C2776694085 @default.
• W2907607280 hasConcept C2776755627 @default.
• W2907607280 hasConcept C2777295375 @default.
• W2907607280 hasConcept C2777389519 @default.
• W2907607280 hasConcept C2778227246 @default.
• W2907607280 hasConcept C2780035454 @default.
• W2907607280 hasConcept C2780147359 @default.

• next