FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907619094> ?p ?o ?g. }

• W2907619094 abstract "Abstract Patient-derived models are transforming translational cancer research. It is not clear if the emergence of patient-derived organoid (PDO) models can extend the utility of the widely used patient-derived xenograft (PDX). In addition, the utility of PDO models for serum biomarker discovery is not known. Here, we demonstrate that PDO models recapitulate the genomics, cell biology, glycomics and drug responses observed in PDX models. Furthermore, we demonstrate the applicability of PDO models for identification of N-glycans that are enriched in the glycome of pancreatic ductal adenocarcinoma (PDAC). Surprisingly, among all the glycans observed in PDX and PDOs, a core set of 57 N-glycans represent 50-94% of the relative abundance of all N-glycans detected, suggesting that only a subset of glycans dominate the cell surface landscape in PDAC. In addition, we outline a tumor organoid-based pipeline to identify surface proteins in extracellular vesicles (EV) from media supernatant of PDO cultures. When combined with the affinity-based validation platform, the EV surface proteins discovered in PDOs are effective in differentiating patients with PDAC from those with benign pancreatitis in the clinic, identifying PDO as powerful discovery platform for serum biomarkers. Thus, PDOs extend the utility of the archival collections of PDX models for translational research and function as a powerful platform for identification of clinically-actionable biomarkers in patients blood. Significance statement Tumor organoids extend the utility of PDX models as platforms for investigating drug response, glycosylation changes and function as new platforms for discovering blood-based biomarkers" @default.
• W2907619094 created "2019-01-11" @default.
• W2907619094 creator A5007775477 @default.
• W2907619094 creator A5008946615 @default.
• W2907619094 creator A5013713025 @default.
• W2907619094 creator A5022881883 @default.
• W2907619094 creator A5023341393 @default.
• W2907619094 creator A5024732613 @default.
• W2907619094 creator A5025381118 @default.
• W2907619094 creator A5033224199 @default.
• W2907619094 creator A5036469612 @default.
• W2907619094 creator A5045917883 @default.
• W2907619094 creator A5048258042 @default.
• W2907619094 creator A5049287519 @default.
• W2907619094 creator A5053125313 @default.
• W2907619094 creator A5060060452 @default.
• W2907619094 creator A5068215639 @default.
• W2907619094 creator A5068892140 @default.
• W2907619094 creator A5073582280 @default.
• W2907619094 creator A5076167474 @default.
• W2907619094 creator A5076978787 @default.
• W2907619094 creator A5078952644 @default.
• W2907619094 creator A5086660695 @default.
• W2907619094 creator A5088766768 @default.
• W2907619094 date "2019-01-07" @default.
• W2907619094 modified "2023-09-23" @default.
• W2907619094 title "Pancreatic tumor organoids for modeling in vivo drug response and discovering clinically-actionable biomarkers" @default.
• W2907619094 cites W1182461782 @default.
• W2907619094 cites W1500925570 @default.
• W2907619094 cites W1787884960 @default.
• W2907619094 cites W1898871412 @default.
• W2907619094 cites W1967293289 @default.
• W2907619094 cites W1986985221 @default.
• W2907619094 cites W1987313243 @default.
• W2907619094 cites W2006481826 @default.
• W2907619094 cites W2043119648 @default.
• W2907619094 cites W2054142953 @default.
• W2907619094 cites W2071997382 @default.
• W2907619094 cites W2103441770 @default.
• W2907619094 cites W2119180969 @default.
• W2907619094 cites W2124476656 @default.
• W2907619094 cites W2136158663 @default.
• W2907619094 cites W2146177965 @default.
• W2907619094 cites W2301744235 @default.
• W2907619094 cites W2417483443 @default.
• W2907619094 cites W2537623931 @default.
• W2907619094 cites W2549542099 @default.
• W2907619094 cites W2613736410 @default.
• W2907619094 cites W2619475721 @default.
• W2907619094 cites W2748710555 @default.
• W2907619094 cites W2751733606 @default.
• W2907619094 cites W2759081117 @default.
• W2907619094 cites W2768331670 @default.
• W2907619094 cites W2791575850 @default.
• W2907619094 cites W2792943960 @default.
• W2907619094 cites W2795334574 @default.
• W2907619094 cites W2807088563 @default.
• W2907619094 cites W2808191072 @default.
• W2907619094 cites W2898938951 @default.
• W2907619094 doi "https://doi.org/10.1101/513267" @default.
• W2907619094 hasPublicationYear "2019" @default.
• W2907619094 type Work @default.
• W2907619094 sameAs 2907619094 @default.
• W2907619094 citedByCount "6" @default.
• W2907619094 countsByYear W29076190942019 @default.
• W2907619094 countsByYear W29076190942020 @default.
• W2907619094 crossrefType "posted-content" @default.
• W2907619094 hasAuthorship W2907619094A5007775477 @default.
• W2907619094 hasAuthorship W2907619094A5008946615 @default.
• W2907619094 hasAuthorship W2907619094A5013713025 @default.
• W2907619094 hasAuthorship W2907619094A5022881883 @default.
• W2907619094 hasAuthorship W2907619094A5023341393 @default.
• W2907619094 hasAuthorship W2907619094A5024732613 @default.
• W2907619094 hasAuthorship W2907619094A5025381118 @default.
• W2907619094 hasAuthorship W2907619094A5033224199 @default.
• W2907619094 hasAuthorship W2907619094A5036469612 @default.
• W2907619094 hasAuthorship W2907619094A5045917883 @default.
• W2907619094 hasAuthorship W2907619094A5048258042 @default.
• W2907619094 hasAuthorship W2907619094A5049287519 @default.
• W2907619094 hasAuthorship W2907619094A5053125313 @default.
• W2907619094 hasAuthorship W2907619094A5060060452 @default.
• W2907619094 hasAuthorship W2907619094A5068215639 @default.
• W2907619094 hasAuthorship W2907619094A5068892140 @default.
• W2907619094 hasAuthorship W2907619094A5073582280 @default.
• W2907619094 hasAuthorship W2907619094A5076167474 @default.
• W2907619094 hasAuthorship W2907619094A5076978787 @default.
• W2907619094 hasAuthorship W2907619094A5078952644 @default.
• W2907619094 hasAuthorship W2907619094A5086660695 @default.
• W2907619094 hasAuthorship W2907619094A5088766768 @default.
• W2907619094 hasBestOaLocation W29076190941 @default.
• W2907619094 hasConcept C104317684 @default.
• W2907619094 hasConcept C106686826 @default.
• W2907619094 hasConcept C108625454 @default.
• W2907619094 hasConcept C121608353 @default.
• W2907619094 hasConcept C124535831 @default.
• W2907619094 hasConcept C153911025 @default.
• W2907619094 hasConcept C158650290 @default.
• W2907619094 hasConcept C185592680 @default.
• W2907619094 hasConcept C206212055 @default.
• W2907619094 hasConcept C2780210213 @default.

• next