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- W2907654890 abstract "Aims: SDF-1/CXCR4 activation facilitates myocardial repair. Since SDF-1 is only upregulated for a short time after myocardial infarction (MI) targeting of regenerative CXCR4+ cells is limited. We aimed to reactivate the HIF-1α target genes SDF-1 and CXCR4 by prolyl hydroxylase inhibition (PHI) to augment CXCR4+ cell recruitment and myocardial repair. Methods and Results: SDF-1 and CXCR4 expression was analysed under normoxia and ischemia ± PHI utilizing SDF-1-EGFP and CXCR4-EGFP reporter mice. In bone marrow (BM) CXCR4-EGFP was predominantly expressed in CD45+/CXCR4-EGFP+/CD11b+ leukocytes. After MI CD45+/CXCR4-EGFP+/CD11b+ leukocytes significantly increased. In the heart CD45+/CXCR4-EGFP+ cells also predominantly co-expressed CD11b+, but also angiogenic CD31+, CD34+, c-kit+, Flk1+ markers, and stem cell populations like ACC133+, and Lin-/c-kit+/Sca-1+ significantly increased after ischemia. In vitro, PHI with 500μM dimethyloxalylglycine (DMOG) upregulated SDF-1 mRNA expression after 24 h in human microva..." @default.
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- W2907654890 date "2016-11-11" @default.
- W2907654890 modified "2023-09-28" @default.
- W2907654890 title "Abstract 18567: Inhibition of Prolyl Hydroxylase to Enhance Sdf-1 Expression for Augmented Cxcr4+ Cell Recruitment and Cardiac Repair" @default.
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