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- W2907659502 abstract "To the best of our knowledge, this is the first study investigating the protective effect of metformin against hyperoxia-induced oxidative and inflammatory damage to the liver, thymus, spleen, kidney and lung tissues of young rats. 40 Wistar albino separated to four equal groups such as: normoxia control group (NC), normoxia plus metformin group (NM, 25 mg/kg of metformin), hyperoxia (≥85% O2) group (HC), hyperoxia plus metformin group (HM, ≥85% O2; 25 mg/kg of metformin). To evaluate the antioxidant effect of metformin on rat tissues, we performed lipid peroxidation, protein oxidation , Na K ATPase activity and antioxidant capacity [ enzymatic: glutathione peroxidase (GP), glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT) activity; non-enzymatic: glutathione (GSH) level] measurements. We also measured serum interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor alfa (TNFα) cytokine levels and nuclear factor kappa B (NF-κB) activation to evaluate the anti-inflammatory effects of metformin. A statistically significant decrease was observed in the HM group in terms of tissue lipid peroxidation, protein oxidation, and DNA fragmentation measurements compared to the HC group, while enzymatic and non-enzymatic antioxidant capacity and Na K ATPase activity increased significantly. In the HM group, plasma IL-1β, IL-6, and TNF-α levels and NF-κB activation. decreased and IL-10 increased significantly compared to the HC group. In conclusion, metformin has a protective role against hyperoxia-induced oxidative and inflammatory damage in the liver, thymus, spleen, kidney and lung tissues of young rats. Key words: hyperoxia, oxidative stress, inflammation," @default.
- W2907659502 created "2019-01-11" @default.
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- W2907659502 date "2018-01-01" @default.
- W2907659502 modified "2023-10-14" @default.
- W2907659502 title "Metformin Attenuated Hyperoxia Induced Oxidative Damages on Different Tissues in Young Rats" @default.
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