FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907663721> ?p ?o ?g. }

• W2907663721 endingPage "704" @default.
• W2907663721 startingPage "697" @default.
• W2907663721 abstract "Triple-negative breast cancer (TNBC) is highly invasive and aggressive and lacks specific molecular targets to improve the prognosis. MicroRNAs (miRNAs) serve a role in promoting and suppressing tumors in various types of malignant cancer, including TNBC. However, the regulatory mechanism of miR-124 in TNBC has still remains unclear.Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of miR-124. Cell viability was analyzed with CCK-8 assay. Cell colony formation ability was detected with colony formation assay. Cell invasion was measured with transwell assay. Dual luciferase reporter assay was conducted to verify whether ZEB2 is a target gene of miR-124. The mRNA and protein expression levels of ZEB2 and EMT markers were detected by quantitative real time PCR and western blot, respectively.Our results showed that miR-124 was down-regulated in TNBC tissues and cells. Overexpression of miR-124 inhibited the proliferation, metastasis and epithelial-mesenchymal transition (EMT) of TNBC cells. Furthermore, ZEB2 3'UTR was considered to be a direct target of miR-124 with luciferase reporter assay. Rescue experiments confirmed that EMT was regulated by miR-124 via suppression of ZEB2.miR-124 suppresses EMT and metastasis via ZEB2. Therefore, miR-124 may represent a potential therapeutic target for TNBC." @default.
• W2907663721 created "2019-01-11" @default.
• W2907663721 creator A5011285271 @default.
• W2907663721 creator A5017190833 @default.
• W2907663721 creator A5048279362 @default.
• W2907663721 creator A5062925533 @default.
• W2907663721 creator A5068164068 @default.
• W2907663721 date "2019-04-01" @default.
• W2907663721 modified "2023-09-30" @default.
• W2907663721 title "miR-124 regulates EMT based on ZEB2 target to inhibit invasion and metastasis in triple-negative breast cancer" @default.
• W2907663721 cites W144423133 @default.
• W2907663721 cites W1505433891 @default.
• W2907663721 cites W1966984662 @default.
• W2907663721 cites W1974650935 @default.
• W2907663721 cites W1976324983 @default.
• W2907663721 cites W1981052185 @default.
• W2907663721 cites W1989236218 @default.
• W2907663721 cites W1996488211 @default.
• W2907663721 cites W2002037400 @default.
• W2907663721 cites W2002995168 @default.
• W2907663721 cites W2007531307 @default.
• W2907663721 cites W2007795568 @default.
• W2907663721 cites W2016399234 @default.
• W2907663721 cites W2019394924 @default.
• W2907663721 cites W2022916389 @default.
• W2907663721 cites W2025647419 @default.
• W2907663721 cites W2039213901 @default.
• W2907663721 cites W2043797012 @default.
• W2907663721 cites W2047529648 @default.
• W2907663721 cites W2055998706 @default.
• W2907663721 cites W2058252240 @default.
• W2907663721 cites W2060799314 @default.
• W2907663721 cites W2060863314 @default.
• W2907663721 cites W2068910226 @default.
• W2907663721 cites W2069935020 @default.
• W2907663721 cites W2073073901 @default.
• W2907663721 cites W2073395804 @default.
• W2907663721 cites W2077749987 @default.
• W2907663721 cites W2083381199 @default.
• W2907663721 cites W2088120068 @default.
• W2907663721 cites W2088321564 @default.
• W2907663721 cites W2090587373 @default.
• W2907663721 cites W2097255042 @default.
• W2907663721 cites W2098891057 @default.
• W2907663721 cites W2099277978 @default.
• W2907663721 cites W2104146201 @default.
• W2907663721 cites W2113810141 @default.
• W2907663721 cites W2120064337 @default.
• W2907663721 cites W2121511636 @default.
• W2907663721 cites W2130979840 @default.
• W2907663721 cites W2131994307 @default.
• W2907663721 cites W2132760472 @default.
• W2907663721 cites W2139030718 @default.
• W2907663721 cites W2139056019 @default.
• W2907663721 cites W2153751115 @default.
• W2907663721 cites W2170177166 @default.
• W2907663721 cites W2171697766 @default.
• W2907663721 cites W2215834291 @default.
• W2907663721 cites W2255743805 @default.
• W2907663721 cites W2542658396 @default.
• W2907663721 cites W2550103077 @default.
• W2907663721 cites W2736050811 @default.
• W2907663721 cites W2767209724 @default.
• W2907663721 cites W2917837889 @default.
• W2907663721 doi "https://doi.org/10.1016/j.prp.2018.12.039" @default.
• W2907663721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30611621" @default.
• W2907663721 hasPublicationYear "2019" @default.
• W2907663721 type Work @default.
• W2907663721 sameAs 2907663721 @default.
• W2907663721 citedByCount "37" @default.
• W2907663721 countsByYear W29076637212019 @default.
• W2907663721 countsByYear W29076637212020 @default.
• W2907663721 countsByYear W29076637212021 @default.
• W2907663721 countsByYear W29076637212022 @default.
• W2907663721 countsByYear W29076637212023 @default.
• W2907663721 crossrefType "journal-article" @default.
• W2907663721 hasAuthorship W2907663721A5011285271 @default.
• W2907663721 hasAuthorship W2907663721A5017190833 @default.
• W2907663721 hasAuthorship W2907663721A5048279362 @default.
• W2907663721 hasAuthorship W2907663721A5062925533 @default.
• W2907663721 hasAuthorship W2907663721A5068164068 @default.
• W2907663721 hasConcept C104317684 @default.
• W2907663721 hasConcept C121608353 @default.
• W2907663721 hasConcept C145059251 @default.
• W2907663721 hasConcept C1491633281 @default.
• W2907663721 hasConcept C150194340 @default.
• W2907663721 hasConcept C161733203 @default.
• W2907663721 hasConcept C2776415932 @default.
• W2907663721 hasConcept C2779013556 @default.
• W2907663721 hasConcept C2780110267 @default.
• W2907663721 hasConcept C502942594 @default.
• W2907663721 hasConcept C530470458 @default.
• W2907663721 hasConcept C53227056 @default.
• W2907663721 hasConcept C54355233 @default.
• W2907663721 hasConcept C76419328 @default.
• W2907663721 hasConcept C86803240 @default.
• W2907663721 hasConceptScore W2907663721C104317684 @default.
• W2907663721 hasConceptScore W2907663721C121608353 @default.

• next