FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907710007> ?p ?o ?g. }

• W2907710007 endingPage "70" @default.
• W2907710007 startingPage "64" @default.
• W2907710007 abstract "Antipsychotic drugs are used to manage symptoms of pediatric psychiatric disorders despite the relative absence of research regarding the long-term effects of these drugs on brain development. Using rats as a model, research has demonstrated that administration of the antipsychotic drug, risperidone, during early postnatal development elevates locomotor activity and sensitivity to the locomotor effects of amphetamine during adulthood. Because risperidone targets neurotransmitter receptors and forebrain regions associated with working memory, the present study determined whether early-life risperidone altered working memory during adulthood and its sensitivity to amphetamine-induced impairment. Female and male rats received subcutaneous (sc) injections of risperidone daily on postnatal days 14-42. Early-life risperidone increased spontaneous locomotor activity and amphetamine-induced hyperactivity during adulthood, although the effects were significantly greater in females. Working memory was tested in an operant-based, delayed non-matching-to-sample task. Early-life risperidone did not affect the percentage of correct choices observed during sessions with 0–8 second delays but impaired performance during sessions with 0–24 second delays. In a subsequent set of tests using 0–24 second delays, amphetamine (0.75 and 1.25 mg/kg, sc) significantly reduced the percentage of correct choices at most delays, but risperidone did not exacerbate this effect. These data suggest that early-life risperidone leads to modest deficits in working memory during adulthood, but does not alter the perturbation of working memory by amphetamine." @default.
• W2907710007 created "2019-01-11" @default.
• W2907710007 creator A5029667644 @default.
• W2907710007 creator A5037886374 @default.
• W2907710007 creator A5052964294 @default.
• W2907710007 creator A5087428187 @default.
• W2907710007 creator A5089251572 @default.
• W2907710007 date "2019-04-01" @default.
• W2907710007 modified "2023-09-25" @default.
• W2907710007 title "The effects of amphetamine on working memory and locomotor activity in adult rats administered risperidone early in life" @default.
• W2907710007 cites W1495797590 @default.
• W2907710007 cites W1516672823 @default.
• W2907710007 cites W1964216558 @default.
• W2907710007 cites W1964684914 @default.
• W2907710007 cites W1969155610 @default.
• W2907710007 cites W1970056072 @default.
• W2907710007 cites W1972460604 @default.
• W2907710007 cites W1985645068 @default.
• W2907710007 cites W1995419446 @default.
• W2907710007 cites W2004448469 @default.
• W2907710007 cites W2004861020 @default.
• W2907710007 cites W2010767351 @default.
• W2907710007 cites W2017665548 @default.
• W2907710007 cites W2022395708 @default.
• W2907710007 cites W2030742716 @default.
• W2907710007 cites W2034773912 @default.
• W2907710007 cites W2041762730 @default.
• W2907710007 cites W2045218440 @default.
• W2907710007 cites W2051261597 @default.
• W2907710007 cites W2056414695 @default.
• W2907710007 cites W2056919088 @default.
• W2907710007 cites W2073793545 @default.
• W2907710007 cites W2080244900 @default.
• W2907710007 cites W2080617748 @default.
• W2907710007 cites W2094604378 @default.
• W2907710007 cites W2102955710 @default.
• W2907710007 cites W2113878979 @default.
• W2907710007 cites W2131135103 @default.
• W2907710007 cites W2148288398 @default.
• W2907710007 cites W2149686029 @default.
• W2907710007 cites W2149926159 @default.
• W2907710007 cites W2151610969 @default.
• W2907710007 cites W2189073920 @default.
• W2907710007 cites W2221715570 @default.
• W2907710007 cites W2333454685 @default.
• W2907710007 cites W2464372024 @default.
• W2907710007 cites W2478797866 @default.
• W2907710007 cites W2735955853 @default.
• W2907710007 cites W2808141866 @default.
• W2907710007 cites W4247442089 @default.
• W2907710007 cites W2007420088 @default.
• W2907710007 doi "https://doi.org/10.1016/j.bbr.2018.12.044" @default.
• W2907710007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6448153" @default.
• W2907710007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30594546" @default.
• W2907710007 hasPublicationYear "2019" @default.
• W2907710007 type Work @default.
• W2907710007 sameAs 2907710007 @default.
• W2907710007 citedByCount "6" @default.
• W2907710007 countsByYear W29077100072020 @default.
• W2907710007 countsByYear W29077100072021 @default.
• W2907710007 countsByYear W29077100072022 @default.
• W2907710007 countsByYear W29077100072023 @default.
• W2907710007 crossrefType "journal-article" @default.
• W2907710007 hasAuthorship W2907710007A5029667644 @default.
• W2907710007 hasAuthorship W2907710007A5037886374 @default.
• W2907710007 hasAuthorship W2907710007A5052964294 @default.
• W2907710007 hasAuthorship W2907710007A5087428187 @default.
• W2907710007 hasAuthorship W2907710007A5089251572 @default.
• W2907710007 hasBestOaLocation W29077100072 @default.
• W2907710007 hasConcept C118552586 @default.
• W2907710007 hasConcept C126322002 @default.
• W2907710007 hasConcept C15744967 @default.
• W2907710007 hasConcept C169760540 @default.
• W2907710007 hasConcept C169900460 @default.
• W2907710007 hasConcept C21963081 @default.
• W2907710007 hasConcept C2776412080 @default.
• W2907710007 hasConcept C2776921671 @default.
• W2907710007 hasConcept C2777193897 @default.
• W2907710007 hasConcept C2780057945 @default.
• W2907710007 hasConcept C2780494398 @default.
• W2907710007 hasConcept C513476851 @default.
• W2907710007 hasConcept C71924100 @default.
• W2907710007 hasConceptScore W2907710007C118552586 @default.
• W2907710007 hasConceptScore W2907710007C126322002 @default.
• W2907710007 hasConceptScore W2907710007C15744967 @default.
• W2907710007 hasConceptScore W2907710007C169760540 @default.
• W2907710007 hasConceptScore W2907710007C169900460 @default.
• W2907710007 hasConceptScore W2907710007C21963081 @default.
• W2907710007 hasConceptScore W2907710007C2776412080 @default.
• W2907710007 hasConceptScore W2907710007C2776921671 @default.
• W2907710007 hasConceptScore W2907710007C2777193897 @default.
• W2907710007 hasConceptScore W2907710007C2780057945 @default.
• W2907710007 hasConceptScore W2907710007C2780494398 @default.
• W2907710007 hasConceptScore W2907710007C513476851 @default.
• W2907710007 hasConceptScore W2907710007C71924100 @default.
• W2907710007 hasLocation W29077100071 @default.
• W2907710007 hasLocation W29077100072 @default.
• W2907710007 hasLocation W29077100073 @default.

• next