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- W2907744157 abstract "Introduction: Randomized controlled trials (RCTs) investigating the efficacy of bone marrow cell (BMC) transplantation in patients with ischemic heart disease have provided discordant results. The true benefits of BMMNC therapy in these patients remain unclear. Hypothesis: We hypothesized that injection of BMCs in patients with ischemic heart disease would lead to an improvement in left ventricular (LV) structure and function. Methods: We performed a systemic review and meta-analysis of data from published RCTs that evaluated the efficacy of BMCs in patients with ischemic heart disease. Our literature search yielded 64 trials enrolling 3690 patients. We observed the effects of cell injection on LV ejection fraction (LVEF), LV end-systolic volume (LVESV), LV end-diastolic volume (LVEDV) and infarct scar size. BMCs were transplanted in patients with either acute myocardial infarction (AMI) or chronic ischemic heart disease (CIHD). Changes in outcomes of interest were analyzed using random-effects meta-analy..." @default.
- W2907744157 created "2019-01-11" @default.
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- W2907744157 date "2017-11-14" @default.
- W2907744157 modified "2023-09-23" @default.
- W2907744157 title "Abstract 19589: Bone Marrow Cells Improve Cardiac Function and Remodeling in Patients With Ischemic Heart Disease" @default.
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