FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907794290> ?p ?o ?g. }

• W2907794290 abstract "Alzheimer's disease is characterized not only by extracellular amyloid plaques and neurofibrillary tangles, but also by microglia-mediated neuroinflammation. Recently, autophagy has been linked to the regulation of the inflammatory response. Thus, we investigated how an impairment of autophagy mediated by BECN1/Beclin1 reduction, as described in Alzheimer's disease patients, would influence cytokine production of microglia. Acutely stimulated microglia from Becn1+/- mice exhibited increased expression of IL-1beta and IL-18 compared to wild-type microglia. Becn1+/-APPPS1 mice also contained enhanced IL-1beta levels. The investigation of the IL-1beta/IL-18 processing pathway showed an elevated number of cells with inflammasomes and increased levels of NLRP3 and cleaved CASP1/Caspase1 in Becn1+/- microglia. Super-resolation microscopy revealed a very close association of NLRP3 aggregates and LC3-positive vesicles. Interestingly, CALCOCO2 colocalized with NLRP3 and its downregulation increased IL-1beta release. These data support the notion that selective autophagy can impact microglia activation by modulating IL-1beta and IL-18 production via NLRP3 degradation and thus present a mechanism how impaired autophagy could contribute to neuroinflammation in Alzheimer's disease." @default.
• W2907794290 created "2019-01-11" @default.
• W2907794290 creator A5000295640 @default.
• W2907794290 creator A5012870235 @default.
• W2907794290 creator A5029483820 @default.
• W2907794290 creator A5061950306 @default.
• W2907794290 creator A5063416309 @default.
• W2907794290 creator A5083257675 @default.
• W2907794290 date "2019-01-07" @default.
• W2907794290 modified "2023-10-17" @default.
• W2907794290 title "Beclin1‐driven autophagy modulates the inflammatory response of microglia via <scp>NLRP</scp> 3" @default.
• W2907794290 cites W1565351177 @default.
• W2907794290 cites W1807054663 @default.
• W2907794290 cites W1841850981 @default.
• W2907794290 cites W1870959432 @default.
• W2907794290 cites W1900818641 @default.
• W2907794290 cites W1929267935 @default.
• W2907794290 cites W1966158216 @default.
• W2907794290 cites W1976845082 @default.
• W2907794290 cites W1978567629 @default.
• W2907794290 cites W1980046478 @default.
• W2907794290 cites W1981649246 @default.
• W2907794290 cites W1985538633 @default.
• W2907794290 cites W1989821468 @default.
• W2907794290 cites W1990271214 @default.
• W2907794290 cites W1993976394 @default.
• W2907794290 cites W1995357368 @default.
• W2907794290 cites W1997572777 @default.
• W2907794290 cites W1998639445 @default.
• W2907794290 cites W2007123036 @default.
• W2907794290 cites W2015449243 @default.
• W2907794290 cites W2019407752 @default.
• W2907794290 cites W2021178651 @default.
• W2907794290 cites W2032370476 @default.
• W2907794290 cites W2042767581 @default.
• W2907794290 cites W2044090829 @default.
• W2907794290 cites W2047923753 @default.
• W2907794290 cites W2048030072 @default.
• W2907794290 cites W2052859130 @default.
• W2907794290 cites W2059996790 @default.
• W2907794290 cites W2064741210 @default.
• W2907794290 cites W2066800765 @default.
• W2907794290 cites W2071695496 @default.
• W2907794290 cites W2076062022 @default.
• W2907794290 cites W2081014274 @default.
• W2907794290 cites W2099540110 @default.
• W2907794290 cites W2099588975 @default.
• W2907794290 cites W2102769637 @default.
• W2907794290 cites W2104655642 @default.
• W2907794290 cites W2107493006 @default.
• W2907794290 cites W2114442515 @default.
• W2907794290 cites W2115886998 @default.
• W2907794290 cites W2124836944 @default.
• W2907794290 cites W2125161802 @default.
• W2907794290 cites W2128948218 @default.
• W2907794290 cites W2139462909 @default.
• W2907794290 cites W2143119237 @default.
• W2907794290 cites W2148898943 @default.
• W2907794290 cites W2153164696 @default.
• W2907794290 cites W2156788921 @default.
• W2907794290 cites W2156979281 @default.
• W2907794290 cites W2164798123 @default.
• W2907794290 cites W2168120687 @default.
• W2907794290 cites W2183675419 @default.
• W2907794290 cites W2340464393 @default.
• W2907794290 cites W2434638516 @default.
• W2907794290 cites W2468948835 @default.
• W2907794290 cites W2501565077 @default.
• W2907794290 cites W2506505475 @default.
• W2907794290 cites W2570920212 @default.
• W2907794290 cites W2592067246 @default.
• W2907794290 cites W2592077895 @default.
• W2907794290 cites W2606648391 @default.
• W2907794290 cites W2743727231 @default.
• W2907794290 cites W2896485223 @default.
• W2907794290 cites W4297810615 @default.
• W2907794290 doi "https://doi.org/10.15252/embj.201899430" @default.
• W2907794290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6376276" @default.
• W2907794290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30617086" @default.
• W2907794290 hasPublicationYear "2019" @default.
• W2907794290 type Work @default.
• W2907794290 sameAs 2907794290 @default.
• W2907794290 citedByCount "145" @default.
• W2907794290 countsByYear W29077942902019 @default.
• W2907794290 countsByYear W29077942902020 @default.
• W2907794290 countsByYear W29077942902021 @default.
• W2907794290 countsByYear W29077942902022 @default.
• W2907794290 countsByYear W29077942902023 @default.
• W2907794290 crossrefType "journal-article" @default.
• W2907794290 hasAuthorship W2907794290A5000295640 @default.
• W2907794290 hasAuthorship W2907794290A5012870235 @default.
• W2907794290 hasAuthorship W2907794290A5029483820 @default.
• W2907794290 hasAuthorship W2907794290A5061950306 @default.
• W2907794290 hasAuthorship W2907794290A5063416309 @default.
• W2907794290 hasAuthorship W2907794290A5083257675 @default.
• W2907794290 hasBestOaLocation W29077942901 @default.
• W2907794290 hasConcept C104317684 @default.
• W2907794290 hasConcept C127561419 @default.
• W2907794290 hasConcept C142724271 @default.
• W2907794290 hasConcept C190283241 @default.

• next