Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907804775> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2907804775 endingPage "133" @default.
- W2907804775 startingPage "127" @default.
- W2907804775 abstract "Chromatin remodeling factors are involved in many cellular processes such as transcription, replication, and DNA damage response by regulating chromatin structure. As one of chromatin remodeling factors, remodeling and spacing factor 1 (RSF1) is recruited at double strand break (DSB) sites and regulates ataxia telangiectasia mutated (ATM) -dependent checkpoint pathway upon DNA damage for the efficient repair. RSF1 is overexpressed in a variety of cancers, but regulation of RSF1 levels remains largely unknown. Here, we showed that protein levels of RSF1 chromatin remodeler are temporally upregulated in response to different DNA damage agents without changing the RSF1 mRNA level. In the absence of SNF2h, a binding partner of RSF1, the RSF1 protein level was significantly diminished. Intriguingly, the level of RSF1-3SA mutant lacking ATM-mediated phosphorylation sites significantly increased, and upregulation of RSF1 levels under DNA damage was not observed in cells overexpressing ATM kinase. Furthermore, failure in the regulation of RSF1 level caused a significant reduction in DNA repair, whereas reconstitution of RSF1, but not of RSF1-3SA mutants, restored DSB repair. Our findings reveal that temporal regulation of RSF1 levels at its post-translational modification by SNF2h and ATM is essential for efficient DNA repair." @default.
- W2907804775 created "2019-01-11" @default.
- W2907804775 creator A5050660886 @default.
- W2907804775 creator A5051102612 @default.
- W2907804775 creator A5055147199 @default.
- W2907804775 creator A5063295942 @default.
- W2907804775 creator A5082225247 @default.
- W2907804775 creator A5085230981 @default.
- W2907804775 date "2018-02-28" @default.
- W2907804775 modified "2023-09-23" @default.
- W2907804775 title "Post-Translational Regulation of the RSF1 Chromatin Remodeler under DNA Damage." @default.
- W2907804775 cites W1643952099 @default.
- W2907804775 cites W1979540894 @default.
- W2907804775 cites W1998163656 @default.
- W2907804775 cites W2007935491 @default.
- W2907804775 cites W2012381968 @default.
- W2907804775 cites W2025209634 @default.
- W2907804775 cites W2027111177 @default.
- W2907804775 cites W2027599519 @default.
- W2907804775 cites W2047664934 @default.
- W2907804775 cites W2072858355 @default.
- W2907804775 cites W2077436902 @default.
- W2907804775 cites W2079111167 @default.
- W2907804775 cites W2093500779 @default.
- W2907804775 cites W2110817748 @default.
- W2907804775 cites W2129707839 @default.
- W2907804775 cites W2145200068 @default.
- W2907804775 cites W2156970346 @default.
- W2907804775 cites W2164326598 @default.
- W2907804775 cites W2331425741 @default.
- W2907804775 cites W2583621343 @default.
- W2907804775 cites W2595322616 @default.
- W2907804775 doi "https://doi.org/10.14348/molcells.2018.2244" @default.
- W2907804775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5824022" @default.
- W2907804775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29385673" @default.
- W2907804775 hasPublicationYear "2018" @default.
- W2907804775 type Work @default.
- W2907804775 sameAs 2907804775 @default.
- W2907804775 citedByCount "5" @default.
- W2907804775 countsByYear W29078047752020 @default.
- W2907804775 countsByYear W29078047752021 @default.
- W2907804775 countsByYear W29078047752022 @default.
- W2907804775 countsByYear W29078047752023 @default.
- W2907804775 crossrefType "journal-article" @default.
- W2907804775 hasAuthorship W2907804775A5050660886 @default.
- W2907804775 hasAuthorship W2907804775A5051102612 @default.
- W2907804775 hasAuthorship W2907804775A5055147199 @default.
- W2907804775 hasAuthorship W2907804775A5063295942 @default.
- W2907804775 hasAuthorship W2907804775A5082225247 @default.
- W2907804775 hasAuthorship W2907804775A5085230981 @default.
- W2907804775 hasConcept C134935766 @default.
- W2907804775 hasConcept C143425029 @default.
- W2907804775 hasConcept C153911025 @default.
- W2907804775 hasConcept C167227067 @default.
- W2907804775 hasConcept C185592680 @default.
- W2907804775 hasConcept C54355233 @default.
- W2907804775 hasConcept C552990157 @default.
- W2907804775 hasConcept C83640560 @default.
- W2907804775 hasConcept C86803240 @default.
- W2907804775 hasConcept C95444343 @default.
- W2907804775 hasConceptScore W2907804775C134935766 @default.
- W2907804775 hasConceptScore W2907804775C143425029 @default.
- W2907804775 hasConceptScore W2907804775C153911025 @default.
- W2907804775 hasConceptScore W2907804775C167227067 @default.
- W2907804775 hasConceptScore W2907804775C185592680 @default.
- W2907804775 hasConceptScore W2907804775C54355233 @default.
- W2907804775 hasConceptScore W2907804775C552990157 @default.
- W2907804775 hasConceptScore W2907804775C83640560 @default.
- W2907804775 hasConceptScore W2907804775C86803240 @default.
- W2907804775 hasConceptScore W2907804775C95444343 @default.
- W2907804775 hasIssue "2" @default.
- W2907804775 hasLocation W29078047751 @default.
- W2907804775 hasOpenAccess W2907804775 @default.
- W2907804775 hasPrimaryLocation W29078047751 @default.
- W2907804775 hasRelatedWork W1979540894 @default.
- W2907804775 hasRelatedWork W1991397664 @default.
- W2907804775 hasRelatedWork W2026495547 @default.
- W2907804775 hasRelatedWork W2056059870 @default.
- W2907804775 hasRelatedWork W2157963865 @default.
- W2907804775 hasRelatedWork W2765372851 @default.
- W2907804775 hasRelatedWork W2811264472 @default.
- W2907804775 hasRelatedWork W2907804775 @default.
- W2907804775 hasRelatedWork W3193638376 @default.
- W2907804775 hasRelatedWork W3203956166 @default.
- W2907804775 hasVolume "41" @default.
- W2907804775 isParatext "false" @default.
- W2907804775 isRetracted "false" @default.
- W2907804775 magId "2907804775" @default.
- W2907804775 workType "article" @default.