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• W2907872880 abstract "ObjectiveTo identify differences in the transcriptomic profiles during placentation from pregnancies conceived spontaneously vs. those with infertility using non-in vitro fertilization (IVF) fertility treatment (NIFT) or IVF.DesignCohort study.SettingAcademic medical center.Patient(s)Women undergoing chorionic villus sampling at gestational age 11–13 weeks (n = 141), with pregnancies that were conceived spontaneously (n = 74), with NIFT (n = 33), or with IVF (n = 34), resulting in the delivery of viable offspring.Intervention(s)Collection of chorionic villus samples from women who conceived spontaneously, with NIFT, or with IVF for gene expression analysis using RNA sequencing.Main Outcome Measure(s)Baseline maternal, paternal, and fetal demographics, maternal medical conditions, pregnancy complications, and outcomes. Differential gene expression of first-trimester placenta.Result(s)There were few differences in the transcriptome of first-trimester placenta from NIFT, IVF, and spontaneous pregnancies. There was one protein-coding differentially expressed gene (DEG) between the spontaneous and infertility groups, CACNA1I, one protein-coding DEG between the spontaneous and IVF groups, CACNA1I, and five protein-coding DEGs between the NIFT and IVF groups, SLC18A2, CCL21, FXYD2, PAEP, and DNER.Conclusion(s)This is the first and largest study looking at transcriptomic profiles of first-trimester placenta demonstrating similar transcriptomic profiles in pregnancies conceived using NIFT or IVF and spontaneous conceptions. Gene expression differences found to be highest in the NIFT group suggest that the underlying infertility, in addition to treatment-related factors, may contribute to the observed gene expression profiles. To identify differences in the transcriptomic profiles during placentation from pregnancies conceived spontaneously vs. those with infertility using non-in vitro fertilization (IVF) fertility treatment (NIFT) or IVF. Cohort study. Academic medical center. Women undergoing chorionic villus sampling at gestational age 11–13 weeks (n = 141), with pregnancies that were conceived spontaneously (n = 74), with NIFT (n = 33), or with IVF (n = 34), resulting in the delivery of viable offspring. Collection of chorionic villus samples from women who conceived spontaneously, with NIFT, or with IVF for gene expression analysis using RNA sequencing. Baseline maternal, paternal, and fetal demographics, maternal medical conditions, pregnancy complications, and outcomes. Differential gene expression of first-trimester placenta. There were few differences in the transcriptome of first-trimester placenta from NIFT, IVF, and spontaneous pregnancies. There was one protein-coding differentially expressed gene (DEG) between the spontaneous and infertility groups, CACNA1I, one protein-coding DEG between the spontaneous and IVF groups, CACNA1I, and five protein-coding DEGs between the NIFT and IVF groups, SLC18A2, CCL21, FXYD2, PAEP, and DNER. This is the first and largest study looking at transcriptomic profiles of first-trimester placenta demonstrating similar transcriptomic profiles in pregnancies conceived using NIFT or IVF and spontaneous conceptions. Gene expression differences found to be highest in the NIFT group suggest that the underlying infertility, in addition to treatment-related factors, may contribute to the observed gene expression profiles." @default.
• W2907872880 created "2019-01-11" @default.
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• W2907872880 date "2019-03-01" @default.
• W2907872880 modified "2023-09-26" @default.
• W2907872880 title "Differential gene expression during placentation in pregnancies conceived with different fertility treatments compared with spontaneous pregnancies" @default.
• W2907872880 cites W1151864206 @default.
• W2907872880 cites W141415844 @default.
• W2907872880 cites W159488697 @default.
• W2907872880 cites W1917821653 @default.
• W2907872880 cites W1988764036 @default.
• W2907872880 cites W1992541066 @default.
• W2907872880 cites W2002831774 @default.
• W2907872880 cites W2003171908 @default.
• W2907872880 cites W2006506621 @default.
• W2907872880 cites W2008840572 @default.
• W2907872880 cites W2014006573 @default.
• W2907872880 cites W2023669179 @default.
• W2907872880 cites W2025803238 @default.
• W2907872880 cites W2026475357 @default.
• W2907872880 cites W2032036679 @default.
• W2907872880 cites W2034089747 @default.
• W2907872880 cites W2034400748 @default.
• W2907872880 cites W2036125503 @default.
• W2907872880 cites W2037840343 @default.
• W2907872880 cites W2039550783 @default.
• W2907872880 cites W2041490610 @default.
• W2907872880 cites W2044148787 @default.
• W2907872880 cites W2051156849 @default.
• W2907872880 cites W2055258188 @default.
• W2907872880 cites W2056509536 @default.
• W2907872880 cites W2058819429 @default.
• W2907872880 cites W2060544523 @default.
• W2907872880 cites W2061673718 @default.
• W2907872880 cites W2066514154 @default.
• W2907872880 cites W2074102566 @default.
• W2907872880 cites W2075968335 @default.
• W2907872880 cites W2077072637 @default.
• W2907872880 cites W2081678861 @default.
• W2907872880 cites W2082353330 @default.
• W2907872880 cites W2084233203 @default.
• W2907872880 cites W2084408710 @default.
• W2907872880 cites W2085099489 @default.
• W2907872880 cites W2086877510 @default.
• W2907872880 cites W2087135943 @default.
• W2907872880 cites W2090141021 @default.
• W2907872880 cites W2094558613 @default.
• W2907872880 cites W2095186023 @default.
• W2907872880 cites W2097297452 @default.
• W2907872880 cites W2098835730 @default.
• W2907872880 cites W2103172302 @default.
• W2907872880 cites W2109896183 @default.
• W2907872880 cites W2112484452 @default.
• W2907872880 cites W2118698236 @default.
• W2907872880 cites W2118929544 @default.
• W2907872880 cites W2120803011 @default.
• W2907872880 cites W2124978752 @default.
• W2907872880 cites W2126503856 @default.
• W2907872880 cites W2137615110 @default.
• W2907872880 cites W2139425213 @default.
• W2907872880 cites W2139923508 @default.
• W2907872880 cites W2141637710 @default.
• W2907872880 cites W2142148337 @default.
• W2907872880 cites W2150695051 @default.
• W2907872880 cites W2152239989 @default.
• W2907872880 cites W2159515834 @default.
• W2907872880 cites W2159578293 @default.
• W2907872880 cites W2160108008 @default.
• W2907872880 cites W2170408710 @default.
• W2907872880 cites W2171127774 @default.
• W2907872880 cites W2171162078 @default.
• W2907872880 cites W2179438025 @default.
• W2907872880 cites W2197124664 @default.
• W2907872880 cites W2238902725 @default.
• W2907872880 cites W2274216264 @default.
• W2907872880 cites W2323326409 @default.
• W2907872880 cites W2337199545 @default.
• W2907872880 cites W2411729015 @default.
• W2907872880 cites W2528293624 @default.

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