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- W2907913215 endingPage "2019" @default.
- W2907913215 startingPage "2009" @default.
- W2907913215 abstract "Abstract BACKGROUND Glutathione S ‐transferases (GSTs) are a superfamily of multifunctional dimeric proteins existing in both prokaryotic and eukaryotic organisms. They are involved in the detoxification of both endogenous and exogenous electrophiles, including insecticides. However, the molecular mechanisms underlying the regulation of GST genes in insects are poorly understood. RESULTS We first identified at least three GST genes involved in resistance to the insecticides chlorpyrifos and cypermethrin. Analysis of upstream sequences revealed that three GSTs ( SeGSTo2 , SeGSTe6 and SeGSTd3 ) harbor the same cap ‘n’ collar C/muscle aponeurosis fibromatosis (CncC/Maf) binding site, and SeGSTo2 and SeGSTe6 contain the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator (AhR/ARNT) binding site. Luciferase reporter assay showed co‐transfection of reporter plasmid containing the SeGSTe6 promoter with CncC and/or Maf expressing constructs significantly boosted transcription. Similarly, AhR and/or ARNT expressing constructs also significantly increased the promoter activities. The co‐transfection of mutated reporter plasmid with CncC/Maf or AhR/ARNT did not increase transcription activity anymore. Constitutive over‐expression of CncC, Maf and AhR was also found in the HZ16 strain, which might be the molecular mechanism for up‐regulated expression of multiple detoxification genes conferring resistance to insecticides. CONCLUSION These results suggest that CncC/Maf and AhR/ARNT coordinately regulate the expression of multiple GST genes involved in insecticide resistance in Spodoptera exigua . © 2019 Society of Chemical Industry" @default.
- W2907913215 created "2019-01-11" @default.
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- W2907913215 creator A5072854024 @default.
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- W2907913215 creator A5084572287 @default.
- W2907913215 date "2019-02-06" @default.
- W2907913215 modified "2023-10-15" @default.
- W2907913215 title "Transcription factors CncC/Maf and AhR/ARNT coordinately regulate the expression of multiple GSTs conferring resistance to chlorpyrifos and cypermethrin in <i>Spodoptera exigua</i>" @default.
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- W2907913215 doi "https://doi.org/10.1002/ps.5316" @default.
- W2907913215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30610747" @default.
- W2907913215 hasPublicationYear "2019" @default.