FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907977380> ?p ?o ?g. }

• W2907977380 endingPage "99" @default.
• W2907977380 startingPage "90" @default.
• W2907977380 abstract "Unfolded protein response (UPR) is an adaptive mechanism allowing the endoplasmic reticulum (ER) to react to an accumulation of unfolded proteins in its lumen, also known as ER stress. The UPR is interconnected with inflammation through several pathways such as reactive oxygen species (ROS) production resulting from the protein folding or alternatively, activation of nuclear factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK) via IRE1, or induction of acute phase response (APR). Lipocalin 2 (LCN2) is one of the APR proteins induced under inflammatory conditions and up-regulated during ER stress. Upon incubation of Lcn2-/- and wild type (wt) primary hepatocytes with tunicamycin (TM) or thapsigargin (TG) we found the Lcn2-/- hepatocytes to react with strong UPR to the ER stress, as evidenced by significantly increased levels of Grp94, Bip and Chop mRNA and protein compared to the wt. TM and TG-treated hepatocytes activated p65 NF-κB and JNK, the pathways that respond to stress stimuli and playing a central role in inflammation and apoptosis, respectively. ER stress further activated and cleaved full-length CREBH/CREB3L3, the hepatocyte specific transcription factor to induce systemic inflammatory responses. Upregulation of the C/EBP homologous protein (CHOP) was very prominent in Lcn2-/- hepatocytes and sustained until 48 h, resulting in hepatocyte apoptosis as evidenced by increased cleaved caspase 3. We also explored the UPR of the Lcn2 null mouse livers in acute intoxication and inflammation stages with a single application of lipopolysaccharide (LPS) or carbon tetrachloride (CCl4). The Lcn2 null mice clearly developed stronger UPR in LPS- and CCl4-induced ER stress compared to the wt. Our findings indicate that the upregulation of LCN2 during ER stress-induced inflammatory responses protects hepatocytes from being overwhelmed by UPR upon liver injury." @default.
• W2907977380 created "2019-01-11" @default.
• W2907977380 creator A5026640403 @default.
• W2907977380 creator A5036125122 @default.
• W2907977380 creator A5053236731 @default.
• W2907977380 creator A5055719124 @default.
• W2907977380 date "2019-03-01" @default.
• W2907977380 modified "2023-09-24" @default.
• W2907977380 title "Liver parenchymal cells lacking Lipocalin 2 (LCN2) are prone to endoplasmic reticulum stress and unfolded protein response" @default.
• W2907977380 cites W1555460575 @default.
• W2907977380 cites W1570321795 @default.
• W2907977380 cites W1880840061 @default.
• W2907977380 cites W1965727325 @default.
• W2907977380 cites W1980438612 @default.
• W2907977380 cites W1986737010 @default.
• W2907977380 cites W1989787732 @default.
• W2907977380 cites W1994564275 @default.
• W2907977380 cites W2013485800 @default.
• W2907977380 cites W2016090590 @default.
• W2907977380 cites W2019192392 @default.
• W2907977380 cites W2033029728 @default.
• W2907977380 cites W2033554865 @default.
• W2907977380 cites W2057322542 @default.
• W2907977380 cites W2066538173 @default.
• W2907977380 cites W2069924169 @default.
• W2907977380 cites W2089198803 @default.
• W2907977380 cites W2110420807 @default.
• W2907977380 cites W2127848114 @default.
• W2907977380 cites W2127906377 @default.
• W2907977380 cites W2130092335 @default.
• W2907977380 cites W2131632095 @default.
• W2907977380 cites W2133644385 @default.
• W2907977380 cites W2136729555 @default.
• W2907977380 cites W2139568257 @default.
• W2907977380 cites W2144065739 @default.
• W2907977380 cites W2154500525 @default.
• W2907977380 cites W2160276873 @default.
• W2907977380 cites W2162695817 @default.
• W2907977380 cites W2172115472 @default.
• W2907977380 cites W2192080449 @default.
• W2907977380 cites W2319727190 @default.
• W2907977380 cites W2766900039 @default.
• W2907977380 cites W2789523895 @default.
• W2907977380 cites W2802046601 @default.
• W2907977380 cites W2901264708 @default.
• W2907977380 cites W4248078302 @default.
• W2907977380 doi "https://doi.org/10.1016/j.cellsig.2019.01.001" @default.
• W2907977380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30615971" @default.
• W2907977380 hasPublicationYear "2019" @default.
• W2907977380 type Work @default.
• W2907977380 sameAs 2907977380 @default.
• W2907977380 citedByCount "14" @default.
• W2907977380 countsByYear W29079773802019 @default.
• W2907977380 countsByYear W29079773802020 @default.
• W2907977380 countsByYear W29079773802021 @default.
• W2907977380 countsByYear W29079773802022 @default.
• W2907977380 countsByYear W29079773802023 @default.
• W2907977380 crossrefType "journal-article" @default.
• W2907977380 hasAuthorship W2907977380A5026640403 @default.
• W2907977380 hasAuthorship W2907977380A5036125122 @default.
• W2907977380 hasAuthorship W2907977380A5053236731 @default.
• W2907977380 hasAuthorship W2907977380A5055719124 @default.
• W2907977380 hasConcept C104317684 @default.
• W2907977380 hasConcept C127561419 @default.
• W2907977380 hasConcept C139447449 @default.
• W2907977380 hasConcept C158617107 @default.
• W2907977380 hasConcept C158619295 @default.
• W2907977380 hasConcept C185592680 @default.
• W2907977380 hasConcept C202751555 @default.
• W2907977380 hasConcept C20299238 @default.
• W2907977380 hasConcept C203014093 @default.
• W2907977380 hasConcept C2776200302 @default.
• W2907977380 hasConcept C2776914184 @default.
• W2907977380 hasConcept C2777146706 @default.
• W2907977380 hasConcept C2777575526 @default.
• W2907977380 hasConcept C2779725641 @default.
• W2907977380 hasConcept C2781331208 @default.
• W2907977380 hasConcept C54458228 @default.
• W2907977380 hasConcept C55493867 @default.
• W2907977380 hasConcept C67705224 @default.
• W2907977380 hasConcept C86803240 @default.
• W2907977380 hasConcept C95444343 @default.
• W2907977380 hasConceptScore W2907977380C104317684 @default.
• W2907977380 hasConceptScore W2907977380C127561419 @default.
• W2907977380 hasConceptScore W2907977380C139447449 @default.
• W2907977380 hasConceptScore W2907977380C158617107 @default.
• W2907977380 hasConceptScore W2907977380C158619295 @default.
• W2907977380 hasConceptScore W2907977380C185592680 @default.
• W2907977380 hasConceptScore W2907977380C202751555 @default.
• W2907977380 hasConceptScore W2907977380C20299238 @default.
• W2907977380 hasConceptScore W2907977380C203014093 @default.
• W2907977380 hasConceptScore W2907977380C2776200302 @default.
• W2907977380 hasConceptScore W2907977380C2776914184 @default.
• W2907977380 hasConceptScore W2907977380C2777146706 @default.
• W2907977380 hasConceptScore W2907977380C2777575526 @default.
• W2907977380 hasConceptScore W2907977380C2779725641 @default.
• W2907977380 hasConceptScore W2907977380C2781331208 @default.
• W2907977380 hasConceptScore W2907977380C54458228 @default.

• next