FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2907978451> ?p ?o ?g. }

• W2907978451 endingPage "19" @default.
• W2907978451 startingPage "5" @default.
• W2907978451 abstract "How can biophysical principles help precision medicine identify rare driver mutations? A major tenet of pragmatic approaches to precision oncology and pharmacology is that driver mutations are very frequent. However, frequency is a statistical attribute, not a mechanistic one. Rare mutations can also act through the same mechanism, and as we discuss below, “latent driver” mutations may also follow the same route, with “helper” mutations. Here, we review how biophysics provides mechanistic guidelines that extend precision medicine. We outline principles and strategies, especially focusing on mutations that drive cancer. Biophysics has contributed profoundly to deciphering biological processes. However, driven by data science, precision medicine has skirted some of its major tenets. Data science embodies genomics, tissue- and cell-specific expression levels, making it capable of defining genome- and systems-wide molecular disease signatures. It classifies cancer driver genes/mutations and affected pathways, and its associated protein structural data guide drug discovery. Biophysics complements data science. It considers structures and their heterogeneous ensembles, explains how mutational variants can signal through distinct pathways, and how allo-network drugs can be harnessed. Biophysics clarifies how one mutation—frequent or rare—can affect multiple phenotypic traits by populating conformations that favor interactions with other network modules. It also suggests how to identify such mutations and their signaling consequences. Biophysics offers principles and strategies that can help precision medicine push the boundaries to transform our insight into biological processes and the practice of personalized medicine. By contrast, “phenotypic drug discovery,” which capitalizes on physiological cellular conditions and first-in-class drug discovery, may not capture the proper molecular variant. This is because variants of the same protein can express more than one phenotype, and a phenotype can be encoded by several variants." @default.
• W2907978451 created "2019-01-11" @default.
• W2907978451 creator A5020262392 @default.
• W2907978451 creator A5021122269 @default.
• W2907978451 creator A5025357844 @default.
• W2907978451 creator A5071084031 @default.
• W2907978451 date "2019-01-04" @default.
• W2907978451 modified "2023-10-15" @default.
• W2907978451 title "Precision medicine review: rare driver mutations and their biophysical classification" @default.
• W2907978451 cites W1541232310 @default.
• W2907978451 cites W1880949099 @default.
• W2907978451 cites W1965076207 @default.
• W2907978451 cites W1965302838 @default.
• W2907978451 cites W1967239133 @default.
• W2907978451 cites W1967824040 @default.
• W2907978451 cites W1974393170 @default.
• W2907978451 cites W1974858693 @default.
• W2907978451 cites W1974987349 @default.
• W2907978451 cites W1978880915 @default.
• W2907978451 cites W1980427440 @default.
• W2907978451 cites W1981831435 @default.
• W2907978451 cites W1982332213 @default.
• W2907978451 cites W1986291163 @default.
• W2907978451 cites W1987365716 @default.
• W2907978451 cites W1987777080 @default.
• W2907978451 cites W1987813440 @default.
• W2907978451 cites W1987982273 @default.
• W2907978451 cites W1989310302 @default.
• W2907978451 cites W1989365013 @default.
• W2907978451 cites W1991773653 @default.
• W2907978451 cites W1995254028 @default.
• W2907978451 cites W1996299724 @default.
• W2907978451 cites W1997362383 @default.
• W2907978451 cites W2004295816 @default.
• W2907978451 cites W2005642805 @default.
• W2907978451 cites W2006221512 @default.
• W2907978451 cites W2011993152 @default.
• W2907978451 cites W2012753533 @default.
• W2907978451 cites W2015610139 @default.
• W2907978451 cites W2016386715 @default.
• W2907978451 cites W2024133961 @default.
• W2907978451 cites W2028279608 @default.
• W2907978451 cites W2031700674 @default.
• W2907978451 cites W2032674711 @default.
• W2907978451 cites W2034269086 @default.
• W2907978451 cites W2038059039 @default.
• W2907978451 cites W2041205020 @default.
• W2907978451 cites W2044433401 @default.
• W2907978451 cites W2048934130 @default.
• W2907978451 cites W2049682677 @default.
• W2907978451 cites W2053180080 @default.
• W2907978451 cites W2059300459 @default.
• W2907978451 cites W2066962978 @default.
• W2907978451 cites W2067833766 @default.
• W2907978451 cites W2070727232 @default.
• W2907978451 cites W2071734901 @default.
• W2907978451 cites W2075391940 @default.
• W2907978451 cites W2077646289 @default.
• W2907978451 cites W2077723503 @default.
• W2907978451 cites W2082046119 @default.
• W2907978451 cites W2083975423 @default.
• W2907978451 cites W2084884919 @default.
• W2907978451 cites W2085581448 @default.
• W2907978451 cites W2092298531 @default.
• W2907978451 cites W2094795801 @default.
• W2907978451 cites W2097164795 @default.
• W2907978451 cites W2099969687 @default.
• W2907978451 cites W2108643617 @default.
• W2907978451 cites W2117692326 @default.
• W2907978451 cites W2123558100 @default.
• W2907978451 cites W2124220720 @default.
• W2907978451 cites W2127245805 @default.
• W2907978451 cites W2134508297 @default.
• W2907978451 cites W2135924325 @default.
• W2907978451 cites W2144948613 @default.
• W2907978451 cites W2144981148 @default.
• W2907978451 cites W2145324047 @default.
• W2907978451 cites W2147466870 @default.
• W2907978451 cites W2157150618 @default.
• W2907978451 cites W2159578281 @default.
• W2907978451 cites W2163042952 @default.
• W2907978451 cites W2165550831 @default.
• W2907978451 cites W2166422945 @default.
• W2907978451 cites W2166771322 @default.
• W2907978451 cites W2167867998 @default.
• W2907978451 cites W2171777347 @default.
• W2907978451 cites W2179389093 @default.
• W2907978451 cites W2193089263 @default.
• W2907978451 cites W2203187780 @default.
• W2907978451 cites W2260312731 @default.
• W2907978451 cites W2262473824 @default.
• W2907978451 cites W2265800909 @default.
• W2907978451 cites W2267520918 @default.
• W2907978451 cites W2278828392 @default.
• W2907978451 cites W2279293113 @default.
• W2907978451 cites W2282990014 @default.
• W2907978451 cites W2285306960 @default.
• W2907978451 cites W2329659234 @default.

• next