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- W2907993655 endingPage "360" @default.
- W2907993655 startingPage "287" @default.
- W2907993655 abstract "Innate immunity is an ancient and conserved defense mechanism against infectious agents. It is activated after pathogen-associated molecular pattern sensing by germline-encoded pattern-recognition receptors, including specialized nucleic acid sensors. In vertebrates, nucleic acid sensing activates the dominant antiviral pathway that induces interferon (IFN) response and enhances antigen-specific adaptive immunity. Although canonical IFN system is absent in invertebrates, nucleic acid stimulation, and viral infection trigger an inducible non-specific antiviral response that exhibits multiple similarities to vertebrate IFN system. Invertebrates lack the adaptive immunity that provides long-term antigen-specific protection from pathogens. Meanwhile, the RNA interference (RNAi) pathway senses viral nucleic acids and triggers the sequence-specific degradation of viral RNAs, thereby representing a specific antiviral mechanism of invertebrates. RNAi provides the primary antiviral response in some invertebrates but plays minimal or no role in vertebrate antiviral immunity. This review summarizes the nucleic acid sensing-mediated antiviral immunity in invertebrates." @default.
- W2907993655 created "2019-01-11" @default.
- W2907993655 creator A5000500229 @default.
- W2907993655 creator A5031636736 @default.
- W2907993655 date "2019-01-01" @default.
- W2907993655 modified "2023-10-12" @default.
- W2907993655 title "Nucleic Acid Sensing in Invertebrate Antiviral Immunity" @default.
- W2907993655 cites W1584891669 @default.
- W2907993655 cites W1647075334 @default.
- W2907993655 cites W1660520074 @default.
- W2907993655 cites W1755844030 @default.
- W2907993655 cites W1778786754 @default.
- W2907993655 cites W1830488268 @default.
- W2907993655 cites W1866089576 @default.
- W2907993655 cites W1963708619 @default.
- W2907993655 cites W1964541411 @default.
- W2907993655 cites W1965893507 @default.
- W2907993655 cites W1966829783 @default.
- W2907993655 cites W1968291943 @default.
- W2907993655 cites W1970541687 @default.
- W2907993655 cites W1972754339 @default.
- W2907993655 cites W1973046318 @default.
- W2907993655 cites W1973510303 @default.
- W2907993655 cites W1976839582 @default.
- W2907993655 cites W1978065453 @default.
- W2907993655 cites W1986875579 @default.
- W2907993655 cites W1988078836 @default.
- W2907993655 cites W1989746162 @default.
- W2907993655 cites W1990871741 @default.
- W2907993655 cites W1992238147 @default.
- W2907993655 cites W1994307864 @default.
- W2907993655 cites W1994942139 @default.
- W2907993655 cites W1996821296 @default.
- W2907993655 cites W1999754407 @default.
- W2907993655 cites W2000177767 @default.
- W2907993655 cites W2001328256 @default.
- W2907993655 cites W2001926990 @default.
- W2907993655 cites W2003281725 @default.
- W2907993655 cites W2003330861 @default.
- W2907993655 cites W2003859935 @default.
- W2907993655 cites W2004742914 @default.
- W2907993655 cites W2005180597 @default.
- W2907993655 cites W2008561516 @default.
- W2907993655 cites W2008770047 @default.
- W2907993655 cites W2010817624 @default.
- W2907993655 cites W2011321489 @default.
- W2907993655 cites W2020210109 @default.
- W2907993655 cites W2020639485 @default.
- W2907993655 cites W2021618307 @default.
- W2907993655 cites W2022478888 @default.
- W2907993655 cites W2028012273 @default.
- W2907993655 cites W2029433700 @default.
- W2907993655 cites W2030379752 @default.
- W2907993655 cites W2033518550 @default.
- W2907993655 cites W2034394542 @default.
- W2907993655 cites W2034771006 @default.
- W2907993655 cites W2035710100 @default.
- W2907993655 cites W2039772376 @default.
- W2907993655 cites W2041349556 @default.
- W2907993655 cites W2042433863 @default.
- W2907993655 cites W2042641363 @default.
- W2907993655 cites W2044193703 @default.
- W2907993655 cites W2044809110 @default.
- W2907993655 cites W2044847186 @default.
- W2907993655 cites W2045297071 @default.
- W2907993655 cites W2047267297 @default.
- W2907993655 cites W2047561028 @default.
- W2907993655 cites W2047738921 @default.
- W2907993655 cites W2050430270 @default.
- W2907993655 cites W2051252016 @default.
- W2907993655 cites W2055807373 @default.
- W2907993655 cites W2057419005 @default.
- W2907993655 cites W2058797960 @default.
- W2907993655 cites W2063310200 @default.
- W2907993655 cites W2064539804 @default.
- W2907993655 cites W2065030830 @default.
- W2907993655 cites W2066905085 @default.
- W2907993655 cites W2067069163 @default.
- W2907993655 cites W2067198893 @default.
- W2907993655 cites W2068955013 @default.
- W2907993655 cites W2070058479 @default.
- W2907993655 cites W2070641840 @default.
- W2907993655 cites W2071319078 @default.
- W2907993655 cites W2074964253 @default.
- W2907993655 cites W2075272296 @default.
- W2907993655 cites W2075457789 @default.
- W2907993655 cites W2076414390 @default.
- W2907993655 cites W2077779522 @default.
- W2907993655 cites W2078105351 @default.
- W2907993655 cites W2081131958 @default.
- W2907993655 cites W2083144347 @default.
- W2907993655 cites W2085030395 @default.
- W2907993655 cites W2087032228 @default.
- W2907993655 cites W2087767674 @default.
- W2907993655 cites W2088335903 @default.
- W2907993655 cites W2094256260 @default.
- W2907993655 cites W2096103683 @default.
- W2907993655 cites W2100097419 @default.