Matches in SemOpenAlex for { <https://semopenalex.org/work/W2908013950> ?p ?o ?g. }
- W2908013950 endingPage "707" @default.
- W2908013950 startingPage "696" @default.
- W2908013950 abstract "Severe rheumatoid cachexia is associated with pronounced loss of muscle and fat mass in patients with advanced rheumatoid arthritis. This condition is associated with dyslipidemia and predisposition to cardiovascular diseases. Circulating levels of triglycerides (TG) and free fatty acids (FFA) have not yet been consistently defined in severe arthritis. Similarly, the metabolism of these lipids in the arthritic liver has not yet been clarified. Aiming at filling these gaps this study presents a characterization of the circulating lipid profile and of the fatty acids uptake and metabolism in perfused livers of rats with adjuvant-induced arthritis. The levels of TG and total cholesterol were reduced in both serum (10–20%) and liver (20–35%) of arthritic rats. The levels of circulating FFA were 40% higher in arthritic rats, possibly in consequence of cytokine-induced adipose tissue lipolysis. Hepatic uptake and oxidation of palmitic and oleic acids was higher in arthritic livers. The phenomenon results possibly from a more oxidized state of the arthritic liver. Indeed, NADPH/NADP+ and NADH/NAD+ ratios were 30% lower in arthritic livers, which additionally presented higher activities of the citric acid cycle driven by both endogenous and exogenous FFA. The lower levels of circulating and hepatic TG possibly are caused by an increased oxidation associated to a reduced synthesis of fatty acids in arthritic livers. These results reveal that the lipid hepatic metabolism in arthritic rats presents a strong catabolic tendency, a condition that should contribute to the marked cachexia described for arthritic rats and possibly for the severe rheumatoid arthritis." @default.
- W2908013950 created "2019-01-11" @default.
- W2908013950 creator A5002976518 @default.
- W2908013950 creator A5009497700 @default.
- W2908013950 creator A5020164379 @default.
- W2908013950 creator A5027219603 @default.
- W2908013950 creator A5035858160 @default.
- W2908013950 creator A5040609824 @default.
- W2908013950 creator A5071839442 @default.
- W2908013950 creator A5078499631 @default.
- W2908013950 creator A5080249333 @default.
- W2908013950 creator A5091443069 @default.
- W2908013950 date "2019-03-01" @default.
- W2908013950 modified "2023-09-30" @default.
- W2908013950 title "Fatty acids uptake and oxidation are increased in the liver of rats with adjuvant-induced arthritis" @default.
- W2908013950 cites W1493962880 @default.
- W2908013950 cites W1583243260 @default.
- W2908013950 cites W1969368363 @default.
- W2908013950 cites W1971581781 @default.
- W2908013950 cites W1974147209 @default.
- W2908013950 cites W1982690950 @default.
- W2908013950 cites W1992872974 @default.
- W2908013950 cites W2001323513 @default.
- W2908013950 cites W2002098989 @default.
- W2908013950 cites W2002746614 @default.
- W2908013950 cites W2003064100 @default.
- W2908013950 cites W2004043546 @default.
- W2908013950 cites W2005995610 @default.
- W2908013950 cites W2010619099 @default.
- W2908013950 cites W2023071988 @default.
- W2908013950 cites W2023092270 @default.
- W2908013950 cites W2028447671 @default.
- W2908013950 cites W2032355755 @default.
- W2908013950 cites W2032997971 @default.
- W2908013950 cites W2037605387 @default.
- W2908013950 cites W2039536423 @default.
- W2908013950 cites W2043910792 @default.
- W2908013950 cites W2068454916 @default.
- W2908013950 cites W2069959649 @default.
- W2908013950 cites W2073708527 @default.
- W2908013950 cites W2082877035 @default.
- W2908013950 cites W2088086126 @default.
- W2908013950 cites W2089090200 @default.
- W2908013950 cites W2096663777 @default.
- W2908013950 cites W2102613664 @default.
- W2908013950 cites W2102812553 @default.
- W2908013950 cites W2103341943 @default.
- W2908013950 cites W2103366079 @default.
- W2908013950 cites W2110826367 @default.
- W2908013950 cites W2115067834 @default.
- W2908013950 cites W2119103976 @default.
- W2908013950 cites W2121477019 @default.
- W2908013950 cites W2128578138 @default.
- W2908013950 cites W2131128085 @default.
- W2908013950 cites W2132235918 @default.
- W2908013950 cites W2135895956 @default.
- W2908013950 cites W2137499656 @default.
- W2908013950 cites W2145615169 @default.
- W2908013950 cites W2148197913 @default.
- W2908013950 cites W2152212771 @default.
- W2908013950 cites W2163336877 @default.
- W2908013950 cites W2164316464 @default.
- W2908013950 cites W2167634619 @default.
- W2908013950 cites W2168526937 @default.
- W2908013950 cites W2172201422 @default.
- W2908013950 cites W2178164598 @default.
- W2908013950 cites W2234792878 @default.
- W2908013950 cites W2327184901 @default.
- W2908013950 cites W2344083676 @default.
- W2908013950 cites W2562858475 @default.
- W2908013950 cites W2600789259 @default.
- W2908013950 cites W2610276218 @default.
- W2908013950 cites W2737581432 @default.
- W2908013950 cites W2992133041 @default.
- W2908013950 doi "https://doi.org/10.1016/j.bbadis.2018.12.019" @default.
- W2908013950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30593897" @default.
- W2908013950 hasPublicationYear "2019" @default.
- W2908013950 type Work @default.
- W2908013950 sameAs 2908013950 @default.
- W2908013950 citedByCount "13" @default.
- W2908013950 countsByYear W29080139502019 @default.
- W2908013950 countsByYear W29080139502020 @default.
- W2908013950 countsByYear W29080139502021 @default.
- W2908013950 countsByYear W29080139502022 @default.
- W2908013950 countsByYear W29080139502023 @default.
- W2908013950 crossrefType "journal-article" @default.
- W2908013950 hasAuthorship W2908013950A5002976518 @default.
- W2908013950 hasAuthorship W2908013950A5009497700 @default.
- W2908013950 hasAuthorship W2908013950A5020164379 @default.
- W2908013950 hasAuthorship W2908013950A5027219603 @default.
- W2908013950 hasAuthorship W2908013950A5035858160 @default.
- W2908013950 hasAuthorship W2908013950A5040609824 @default.
- W2908013950 hasAuthorship W2908013950A5071839442 @default.
- W2908013950 hasAuthorship W2908013950A5078499631 @default.
- W2908013950 hasAuthorship W2908013950A5080249333 @default.
- W2908013950 hasAuthorship W2908013950A5091443069 @default.
- W2908013950 hasConcept C126322002 @default.
- W2908013950 hasConcept C134018914 @default.