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• W2908030809 abstract "Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors.We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs).Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki-67.The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki-67 may be useful diagnostic markers for CXPA." @default.
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• W2908030809 date "2019-01-16" @default.
• W2908030809 modified "2023-10-12" @default.
• W2908030809 title "Fatty acid synthase and Ki‐67 immunoexpression can be useful for the identification of malignant component in carcinoma ex‐pleomorphic adenoma" @default.
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• W2908030809 doi "https://doi.org/10.1111/jop.12820" @default.
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