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- W2908034985 endingPage "1791" @default.
- W2908034985 startingPage "1780" @default.
- W2908034985 abstract "RNA is accurately entangled in virtually all pathways that maintain cellular homeostasis. To name but a few, RNA is the messenger between DNA encoded information and the resulting proteins. Furthermore, RNAs regulate diverse processes by forming DNA::RNA or RNA::RNA interactions. Finally, RNA itself can be the scaffold for ribonucleoprotein complexes, for example, ribosomes or cellular bodies. Consequently, disruption of any of these processes can lead to disease. This review describes known and emerging RNA-based disease mechanisms like interference with regular splicing, the anomalous appearance of RNA-protein complexes and uncommon RNA species, as well as non-canonical translation. Due to the complexity and entanglement of the above-mentioned pathways, only few drugs are available that target RNA-based disease mechanisms. However, advances in our understanding how RNA is involved in and modulates cellular homeostasis might pave the way to novel treatments." @default.
- W2908034985 created "2019-01-11" @default.
- W2908034985 creator A5065203488 @default.
- W2908034985 date "2019-04-01" @default.
- W2908034985 modified "2023-09-29" @default.
- W2908034985 title "RNA-Mediated Disease Mechanisms in Neurodegenerative Disorders" @default.
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