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• W2908102443 abstract "The DNA polymerase δ catalytic subunit (PolD1) is a highly conserved protein with established functions in both the nucleus and the cytoplasm: whereas PolD1 participates in the replication and repair of nuclear DNA, it plays a role in the control of cytoplasmic microtubule growth by directly acting on microtubule-nucleator γ-tubulin ring complexes. Here, we show that PolD1 shuttles between the nucleus and the cytoplasm. PolD1 harbors two nuclear localization signals that mediate the active transport of PolD1 to the nucleus; conversely, PolD1 is exported from the nucleus by the exportin CRM1-dependent mechanism, a major nuclear-export pathway that mediates the export of various cargos. These findings suggest that the nucleocytoplasmic distribution of PolD1 is influenced by both the nuclear import and export activities of the protein." @default.
• W2908102443 created "2019-01-11" @default.
• W2908102443 creator A5005234975 @default.
• W2908102443 creator A5049410725 @default.
• W2908102443 creator A5067315247 @default.
• W2908102443 date "2019-02-01" @default.
• W2908102443 modified "2023-09-30" @default.
• W2908102443 title "The catalytic subunit of DNA polymerase δ is a nucleocytoplasmic shuttling protein" @default.
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• W2908102443 doi "https://doi.org/10.1016/j.yexcr.2019.01.003" @default.
• W2908102443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30625304" @default.
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