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- W2908137739 endingPage "546" @default.
- W2908137739 startingPage "535" @default.
- W2908137739 abstract "Despite many efforts to improve the outcome of pancreatic ductal adenocarcinoma (PDAC), its prognosis remains poor, which is mostly related to late diagnosis and drug resistance. Improving systemic therapy is considered the major challenge in improving the outcome of this disease.This review covers novel chemotherapy and targeted agents in the treatment of PDAC, with a focus on advanced stage disease.Current frontline therapies used in the treatment of patients with PDAC with favorable performance status are gemcitabine (GEM) and nab-paclitaxel or 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX). PDAC has a number of genetic mutations that may explain its biological behavior, such as KRAS, p53 and CDK2NA, which occur in more than 90% of cases. Unfortunately, to this day, a specific targeting agent to any of those frequent gene mutations is lacking. Emerging areas of targeted therapies include the DNA repair, stroma, metabolism, and stem cells. Immunotherapy with either vaccines or immune checkpoint inhibitors has not produced any significant improvements in outcome of PDAC. Incorporating different approaches in therapy, including conventional, immunological, and others, is key in offering patients with the best possible care." @default.
- W2908137739 created "2019-01-11" @default.
- W2908137739 creator A5011312785 @default.
- W2908137739 creator A5011817630 @default.
- W2908137739 creator A5026049304 @default.
- W2908137739 creator A5085875893 @default.
- W2908137739 date "2018-12-28" @default.
- W2908137739 modified "2023-10-18" @default.
- W2908137739 title "Pharmacotherapeutic strategies for treating pancreatic cancer: advances and challenges" @default.
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