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- W2908170356 abstract "Context The combination of two beneficial antidiabetes interventions, regular exercise and pharmaceuticals, is intuitively appealing. However, metformin, the most commonly prescribed diabetes medication, attenuates the favorable physiological adaptations to exercise; in turn, exercise may impede the action of metformin. Objective We sought to determine the influence of an alternative diabetes treatment, sodium glucose cotransporter 2 (SGLT2) inhibition, on the response to endurance exercise training. Design, participants, and intervention In a randomized, double-blind, repeated measures parallel design, 30 sedentary overweight and obese men and women were assigned to 12 weeks of supervised endurance exercise training, with daily ingestion of either a placebo or SGLT2 inhibitor (dapagliflozin: ≤10 mg/day). Outcome measurements and results Endurance exercise training favorably modified body mass, body composition (dual-energy x-ray absorptiometry), peak oxygen uptake (graded exercise with indirect calorimetry), responses to standardized submaximal exercise (indirect calorimetry, heart rate, and blood lactate), and skeletal muscle (vastus lateralis) citrate synthase activity (main effects of exercise training, all P 0.05). However, after endurance exercise training, fasting blood glucose was greater with SGLT2 inhibition, and increased insulin sensitivity (oral glucose tolerance test/Matsuda index) was abrogated with SGLT2 inhibition (exercise training × treatment interaction, P Conclusion The efficacy of combining two beneficial antidiabetes interventions, regular endurance exercise and SGLT2 inhibition, was not supported. SGLT2 inhibition blunted endurance exercise training-induced improvements in insulin sensitivity, independent of effects on aerobic fitness or body composition." @default.
- W2908170356 created "2019-01-11" @default.
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- W2908170356 date "2018-12-28" @default.
- W2908170356 modified "2023-10-01" @default.
- W2908170356 title "Influence of Sodium Glucose Cotransporter 2 Inhibition on Physiological Adaptation to Endurance Exercise Training" @default.
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- W2908170356 cites W1969222185 @default.
- W2908170356 cites W1974187375 @default.
- W2908170356 cites W2001848843 @default.
- W2908170356 cites W2002810160 @default.
- W2908170356 cites W2004008756 @default.
- W2908170356 cites W2013325981 @default.
- W2908170356 cites W2014020546 @default.
- W2908170356 cites W2015191704 @default.
- W2908170356 cites W2021517048 @default.
- W2908170356 cites W2043848757 @default.
- W2908170356 cites W2046436288 @default.
- W2908170356 cites W2050255900 @default.
- W2908170356 cites W2050768254 @default.
- W2908170356 cites W2057406713 @default.
- W2908170356 cites W2069647450 @default.
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- W2908170356 cites W2095612117 @default.
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- W2908170356 cites W2100431456 @default.
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- W2908170356 cites W2127974247 @default.
- W2908170356 cites W2130399139 @default.
- W2908170356 cites W2133795831 @default.
- W2908170356 cites W2138979740 @default.
- W2908170356 cites W2143588920 @default.
- W2908170356 cites W2148513135 @default.
- W2908170356 cites W2149973065 @default.
- W2908170356 cites W2151817522 @default.
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- W2908170356 cites W2160088494 @default.
- W2908170356 cites W2167403702 @default.
- W2908170356 cites W2172193326 @default.
- W2908170356 cites W2218964402 @default.
- W2908170356 cites W2315817175 @default.
- W2908170356 cites W2341611738 @default.
- W2908170356 cites W2549647244 @default.
- W2908170356 cites W2558297083 @default.
- W2908170356 cites W2559854174 @default.
- W2908170356 cites W2572360735 @default.
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- W2908170356 cites W2607569327 @default.
- W2908170356 cites W2625785293 @default.
- W2908170356 cites W2774805246 @default.
- W2908170356 cites W2789034072 @default.
- W2908170356 cites W2801815064 @default.
- W2908170356 cites W2806646741 @default.
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- W2908170356 cites W2884106931 @default.
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- W2908170356 doi "https://doi.org/10.1210/jc.2018-01741" @default.
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