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- W2908198091 abstract "Introduction: Higher HDL-C is considered atheroprotective; however, extremely elevated HDL-C may confer increased atherosclerotic cardiovascular disease (ASCVD) risk. Elevated lipoprotein (a) [Lp(a)] is a known independent risk factor for ASCVD. We hypothesized that those with both extremely elevated HDL-C and Lp(a) would have accentuated adverse metabolic and atherosclerosis phenotypes. Methods: Participants were included from the probability-based multi-ethnic Dallas Heart Study who had risk factor measurements, MRI, DXA, and coronary calcium (CAC). High HDL-C was defined as greater than the 90th race- and sex-specific percentile, and high Lp(a) was defined as greater than the 80th race- and sex-specific percentile. Four groups were constructed to compare risk factors: high HDL-C/high Lp(a), high HDL-C alone, high Lp(a) alone, and neither high. Multivariable adjusted linear regression models were used to assess the cross-sectional association between high HDL-C/high Lp(a) relative to the neither high gr..." @default.
- W2908198091 created "2019-01-11" @default.
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- W2908198091 date "2017-11-14" @default.
- W2908198091 modified "2023-09-23" @default.
- W2908198091 title "Abstract 18821: Extreme Elevations in Both HDL-C and Lp(a), Adiposity, and Subclinical Atherosclerosis in a Multi-ethnic Population-based Cohort: Observation From The Dallas Heart Study" @default.
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