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- W2908246262 abstract "Abstract The aim of current study is to highlight the association between predisposition to multiple sclerosis (MS) and single nucleotide polymorphisms (SNPs) of interleukin-2 (IL2−330 and IL2+166) and transforming growth factor-beta (TGFβ1+869 and TGFβ1+915) genes. A total of 68 Iraqi Arab MS patients and 158 age-gender-ethnicity matched healthy subjects were enrolled in this study to determine the genotypes / alleles of IL2−330, IL2+166, TGFβ1+869 and TGFβ1+915 SNPs using sequence-specific primer polymerase chain reaction (SSP-PCR). Significant increased frequencies of GG genotype and G allele of IL2+166 SNP was observed in MS patients as compared to controls (77.9% vs. 31.7%, P = .000, OR = 7.6; 85% vs. 60%, P = .00, OR = 3.7, respectively). The frequency of TGFβ1+915 SNP GG genotype and G allele were also significantly higher in patients than in controls (72.1% vs. 48.7%, P = .002, OR = 2.7; 85% vs. 70%, P = .001, OR = 2.4, respectively). There was a complete linkage disequilibrium (LD) between −330 and + 166 SNPs of IL2, whereas LD was absent from TGFβ1 SNPs in MS patients. Additionally, TG haplotype of IL2–330,+166 and CG haplotype of TGFβ1+869, +915 showed a significant increased distribution in patients rather than in controls (37.2% vs. 21.8%, P = .000, OR = 2.2; 46.3 vs. 33.1%, P = .008, OR = 1.7, respectively). Consequently, GG genotype / G alleles and TG haplotype of IL2–330,+166 and GG genotype / G alleles and CG haplotype TGFβ1+869, +915 may comprise risk factors for susceptibility to MS in this sample of Iraqi population." @default.
- W2908246262 created "2019-01-11" @default.
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- W2908246262 date "2019-02-01" @default.
- W2908246262 modified "2023-09-28" @default.
- W2908246262 title "The association between multiple sclerosis and genetic variations of TGFβ1 and IL2 genes in Iraqi patients" @default.
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- W2908246262 doi "https://doi.org/10.1016/j.mgene.2019.01.001" @default.
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