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• W2908257415 endingPage "59" @default.
• W2908257415 startingPage "59" @default.
• W2908257415 abstract "Factors underlying disturbed appetite perception in anorexia nervosa (AN) are poorly characterized. We examined in patients with AN whether fasting and postprandial appetite perceptions, gastrointestinal (GI) hormones, GI symptoms and state anxiety (i) differed from healthy controls (HCs) and (ii) were modified by two weeks of refeeding. 22 female adolescent inpatients with restricting AN, studied on hospital admission once medically stable (Wk0), and after one (Wk1) and two (Wk2) weeks of high-calorie refeeding, were compared with 17 age-matched HCs. After a 4 h fast, appetite perceptions, GI symptoms, state anxiety, and plasma acyl-ghrelin, cholecystokinin (CCK), peptide tyrosine tyrosine (PYY) and pancreatic polypeptide (PP) concentrations were assessed at baseline and in response to a mixed-nutrient test-meal (479 kcal). Compared with HCs, in patients with AN at Wk0, baseline ghrelin, PYY, fullness, bloating and anxiety were higher, and hunger less, and in response to the meal, ghrelin, bloating and anxiety were greater, and hunger less (all p < 0.05). After two weeks of refeeding, there was no change in baseline or postprandial ghrelin or bloating, or postprandial anxiety, but baseline PYY, fullness and anxiety decreased, and baseline and postprandial hunger increased (p < 0.05). We conclude that in AN, refeeding for 2 weeks was associated with improvements in PYY, appetite and baseline anxiety, while increased ghrelin, bloating and postprandial anxiety persisted." @default.
• W2908257415 created "2019-01-11" @default.
• W2908257415 creator A5002507515 @default.
• W2908257415 creator A5009002289 @default.
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• W2908257415 creator A5053303292 @default.
• W2908257415 creator A5069463167 @default.
• W2908257415 creator A5091845640 @default.
• W2908257415 date "2018-12-28" @default.
• W2908257415 modified "2023-10-06" @default.
• W2908257415 title "Appetite Perceptions, Gastrointestinal Symptoms, Ghrelin, Peptide YY and State Anxiety are Disturbed in Adolescent Females with Anorexia Nervosa and Only Partially Restored with Short-Term Refeeding" @default.
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• W2908257415 doi "https://doi.org/10.3390/nu11010059" @default.
• W2908257415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6356798" @default.
• W2908257415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30597915" @default.
• W2908257415 hasPublicationYear "2018" @default.
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• W2908257415 hasAuthorship W2908257415A5046899456 @default.

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