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- W2908341926 endingPage "20" @default.
- W2908341926 startingPage "7" @default.
- W2908341926 abstract "The cell adhesion molecule neuroligin2 (NLGN2) regulates GABAergic synapse development, but its role in neural circuit function in the adult hippocampus is unclear. We investigated GABAergic synapses and hippocampus-dependent behaviors following viral-vector-mediated overexpression of NLGN2. Transducing hippocampal neurons with AAV-NLGN2 increased neuronal expression of NLGN2 and membrane localization of GABAergic postsynaptic proteins gephyrin and GABAARγ2, and presynaptic vesicular GABA transporter protein (VGAT) suggesting trans-synaptic enhancement of GABAergic synapses. In contrast, glutamatergic postsynaptic density protein-95 (PSD-95) and presynaptic vesicular glutamate transporter (VGLUT) protein were unaltered. Moreover, AAV-NLGN2 significantly increased parvalbumin immunoreactive (PV+) synaptic boutons co-localized with postsynaptic gephyrin+ puncta. Furthermore, these changes were demonstrated to lead to cognitive impairments as shown in a battery of hippocampal-dependent mnemonic tasks and social behaviors." @default.
- W2908341926 created "2019-01-11" @default.
- W2908341926 creator A5008938024 @default.
- W2908341926 creator A5009962764 @default.
- W2908341926 creator A5013681082 @default.
- W2908341926 creator A5013773614 @default.
- W2908341926 creator A5081290933 @default.
- W2908341926 creator A5089161641 @default.
- W2908341926 date "2019-04-01" @default.
- W2908341926 modified "2023-09-26" @default.
- W2908341926 title "Adeno-associated viral overexpression of neuroligin 2 in the mouse hippocampus enhances GABAergic synapses and impairs hippocampal-dependent behaviors" @default.
- W2908341926 cites W1475594716 @default.
- W2908341926 cites W1544607115 @default.
- W2908341926 cites W1553785885 @default.
- W2908341926 cites W1967872727 @default.
- W2908341926 cites W1968604844 @default.
- W2908341926 cites W1970792572 @default.
- W2908341926 cites W1970867439 @default.
- W2908341926 cites W1974741249 @default.
- W2908341926 cites W1979317809 @default.
- W2908341926 cites W1980944036 @default.
- W2908341926 cites W1981877284 @default.
- W2908341926 cites W1982095045 @default.
- W2908341926 cites W1984095888 @default.
- W2908341926 cites W1987087112 @default.
- W2908341926 cites W1988011192 @default.
- W2908341926 cites W1993508868 @default.
- W2908341926 cites W1997497060 @default.
- W2908341926 cites W1999766029 @default.
- W2908341926 cites W2002541676 @default.
- W2908341926 cites W2003966687 @default.
- W2908341926 cites W2004747469 @default.
- W2908341926 cites W2006302371 @default.
- W2908341926 cites W2007430976 @default.
- W2908341926 cites W2009338110 @default.
- W2908341926 cites W2010031803 @default.
- W2908341926 cites W2011504521 @default.
- W2908341926 cites W2023179463 @default.
- W2908341926 cites W2023768217 @default.
- W2908341926 cites W2025176554 @default.
- W2908341926 cites W2030396712 @default.
- W2908341926 cites W2030492864 @default.
- W2908341926 cites W2033851827 @default.
- W2908341926 cites W2036451206 @default.
- W2908341926 cites W2037116272 @default.
- W2908341926 cites W2037820041 @default.
- W2908341926 cites W2038872732 @default.
- W2908341926 cites W2040188303 @default.
- W2908341926 cites W2042894225 @default.
- W2908341926 cites W2046165746 @default.
- W2908341926 cites W2046922635 @default.
- W2908341926 cites W2047450158 @default.
- W2908341926 cites W2050080293 @default.
- W2908341926 cites W2050243692 @default.
- W2908341926 cites W2050465941 @default.
- W2908341926 cites W2052515926 @default.
- W2908341926 cites W2052628586 @default.
- W2908341926 cites W2052714236 @default.
- W2908341926 cites W2055720472 @default.
- W2908341926 cites W2059215368 @default.
- W2908341926 cites W2065291833 @default.
- W2908341926 cites W2072885702 @default.
- W2908341926 cites W2078139702 @default.
- W2908341926 cites W2082977189 @default.
- W2908341926 cites W2083327596 @default.
- W2908341926 cites W2085955152 @default.
- W2908341926 cites W2087967248 @default.
- W2908341926 cites W2090610674 @default.
- W2908341926 cites W2094366691 @default.
- W2908341926 cites W2098277878 @default.
- W2908341926 cites W2098430271 @default.
- W2908341926 cites W2098807436 @default.
- W2908341926 cites W2102186066 @default.
- W2908341926 cites W2106170163 @default.
- W2908341926 cites W2108224079 @default.
- W2908341926 cites W2109091674 @default.
- W2908341926 cites W2113177792 @default.
- W2908341926 cites W2114093008 @default.
- W2908341926 cites W2116011820 @default.
- W2908341926 cites W2119747299 @default.
- W2908341926 cites W2121124984 @default.
- W2908341926 cites W2124894709 @default.
- W2908341926 cites W2125147395 @default.
- W2908341926 cites W2129904696 @default.
- W2908341926 cites W2131701641 @default.
- W2908341926 cites W2133218270 @default.
- W2908341926 cites W2138596583 @default.
- W2908341926 cites W2144531560 @default.
- W2908341926 cites W2147152912 @default.
- W2908341926 cites W2151594784 @default.
- W2908341926 cites W2151845878 @default.
- W2908341926 cites W2152860360 @default.
- W2908341926 cites W2155203515 @default.
- W2908341926 cites W2156771183 @default.
- W2908341926 cites W2158438953 @default.
- W2908341926 cites W2158466578 @default.
- W2908341926 cites W2158556702 @default.
- W2908341926 cites W2162845416 @default.