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- W2908361545 abstract "e14650 Background: Epithelial membrane protein 2 (EMP2), a 4-transmembrane protein, has a discrete tissue distribution, with high expression in secretory endometrium, lung alveolar epithelium, and in retinal pigmented epithelium within the eye. Dysregulation of EMP2 has been implicated in endometrial cancer, in which EMP2 expression correlates with poor prognosis and survival. Methods: Colorectal cancer (CRC) is the third form of cancer in both men and women. EMT is a critical early event involved in invasion and metastasis of colorectal cancer. But its mechanism is unclear. Here, we investigated the molecular mechanism underlying Epithelial membrane protein 2 (EMP2) in the process of EMT in colon carcinoma and the clinical relevance of EMP2 in human colon cancer. Results: Our study firstly identifies the EMP2 inhibits the process of EMT in human colon cancer cells and in zebrafish animal models. In this process, it is very important that EMP2 can interact with integrin α5β1 and degrade it by increasing u..." @default.
- W2908361545 created "2019-01-11" @default.
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- W2908361545 date "2014-05-20" @default.
- W2908361545 modified "2023-09-23" @default.
- W2908361545 title "Epithelial membrane protein 2 and inhibition of epithelial mesenchymal transition by interaction with integrin α5β1 and induction its ubiquitination in colon cancer." @default.
- W2908361545 doi "https://doi.org/10.1200/jco.2014.32.15_suppl.e14650" @default.
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