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• W2908367089 endingPage "781b" @default.
• W2908367089 startingPage "747" @default.
• W2908367089 abstract "This chapter reviews data showing that Fibroblast Growth Factors (FGF) are a family of related factors playing fundamental roles in several biological processes involving tissue remodeling such as embryonic development, angiogenesis, wound healing, nerve regeneration, chronic inflammation, and cancer. These processes are dependent on several biologic responses mediated by FGFs, including cell survival, proliferation, migration, invasion, and differentiation. The capability of FGFs to elicit many different responses through intracrine, autocrine, and paracrine actions confers a notable plasticity. FGFs also play a key role in hematopoiesis, and have neurotrophic properties. These studies have increased knowledge about the structure of both FGF, and FGFR proteins, their stability in vivo, the mechanisms of FGF production, export, import and cell trafficking, regulation of their functions by ECM molecules, the structure of FGFR in complex with their ligands, and the role and mechanisms of FGFR signaling in several biologic models. Recent studies have attempted to identify specific FGF signaling pathways underlying different responses. FGF-dependent cell migration appears to be preferentially dependent on Src and p38 MAP kinase activation, whereas cell proliferation is dependent on ERKs. The complexity of FGF mediated processes represents an extraordinary challenge to future research. The study of the role of FGFs and FGFRs in pathologic conditions including developmental disorders and syndromes, angiogenic diseases, chronic inflammation, neurologic syndromes, hyperplastic, reactive diseases, and cancer, has greatly increased the knowledge of FGF actions, and led to the identification of new therapeutic molecular targets." @default.
• W2908367089 created "2019-01-11" @default.
• W2908367089 creator A5039631860 @default.
• W2908367089 creator A5043236733 @default.
• W2908367089 creator A5053117986 @default.
• W2908367089 creator A5071331497 @default.
• W2908367089 date "2003-01-01" @default.
• W2908367089 modified "2023-09-25" @default.
• W2908367089 title "The fibroblast growth factors" @default.
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